Alprazolam

When ATH:
N05BA12

Characteristic.

Anxiolytic, benzodiazepine derivative. White or white with blue polka crystalline powder. Insoluble in water and slightly soluble in alcohol.

Pharmacological action.
Anxiolytic, sedation, miorelaksiruyuschee, central.

Application.

Neurosis and psychopathy, accompanied by fear, anxiously, concern; reactive depression (incl. against the background of systemic diseases), panic disorder, withdrawal symptoms in patients with alcoholism and drug addiction.

Contraindications.

Hypersensitivity, severe respiratory failure, glaucoma (acute attack), acute liver disease and kidney failure, myasthenia, pregnancy (especially I trimester), lactation, Age to 18 years.

Restrictions apply.

Otkrыtougolynaya glaucoma, sleep apnea, chronic renal and / or hepatic insufficiency, alcoholic liver disease.

Pregnancy and breast-feeding.

Category actions result in FDA - D. (There is evidence of the risk of adverse effects of drugs on the human fetus, obtained in research or practice, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk, if the drug is needed in life-threatening situations or severe disease, when safer agents should not be used or are ineffective.)

Side effects.

Drowsiness, fatigue, dizziness, unsteadiness of gait, mental retardation and motor responses, poor concentration, nausea, constipation, dysmenorrhoea, decreased libido, itching, paradoxical reactions (aggressiveness, excitation, irritability, anxiety, hallucinations), adaptation, drug dependence, withdrawal.

Cooperation.

It enhances the effect of alcohol, neuroleptics and hypnotics, narcotic analgesics, Central muscle relaxants.

Overdose.

Symptoms: CNS depression of varying severity (from drowsiness to coma) -drowsiness, confusion; In more severe cases, (particularly in patients receiving other drugs, CNS depressants, or alcohol) -ataxia, reduced reflexes, gipotenziya, coma.

Treatment: induction of vomiting, gastric lavage, simptomaticheskaya therapy, monitoring vital functions. When expressed hypotension is a norepinephrine. Specific antidote-BZ antagonist Flumazenil receptors (introduction only in the hospital).

Dosing and Administration.

Inside. The mode set individually, depending on the disease, portability, etc.. Treatment should start with the lowest effective dose. The initial dose for adults-0.25-0.5 mg 3 once a day, with good endurance (in case of need) may increase the dose every 3-4 days. The maximum daily dose is 3-4 mg.

Precautions.

It should be taken into account, that anxiety or stress, associated with daily stress, usually does not require treatment with anxiolytics.

In the event of paradoxical reactions need to stop taking the drug. In the period of treatment is unacceptable consumption of alcoholic beverages. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cooperation