Fexofenadine

When ATH:
R06AX26

Characteristic.

Fexofenadine hydrochloride is a white or colorless crystalline powder. Easily soluble in methanol and ethanol, slightly soluble in chloroform and water, insoluble hexane.

Pharmacological action.
Antihistamine, antiallergic.

Application.

Nasal allergy (vasomotor, season), pollen disease, hives.

Contraindications.

Hypersensitivity, Children up to age 6 years.

Restrictions apply.

Chronic renal failure, hepatic failure, pregnancy, lactation.

Pregnancy and breast-feeding.

Maybe, if the effect of therapy outweighs the potential risk to the fetus and newborn.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

From the nervous system: headache, rarely, dizziness, drowsiness or insomnia, < 1% -fatigue, weakness.

From the digestive tract: < 2% - Nausea, dyspepsia, constipation.

From the respiratory system: seldom-CSF, viral upper respiratory tract infection, pain in the throat and chest.

Cardio-vascular system and blood: rarely - leukopenia, anemia.

Other: < 1,5% - Back pain, myalgia, giperʙiliruʙinemija, hyperlipidemia, AST increase, rarely is dysmenorrhea.

Cooperation.

Erythromycin and ketoconazole increases plasma levels (incidence of side effects is not changed). Antacids, containing aluminum or magnesium hydroxide, reduce bioavailability (When you receive should be an interval of at least 2 no). Compatible with omeprazole. It reinforces the effect of alcohol on the central nervous system.

Overdose.

Symptoms: dizziness, drowsiness, dry mouth.

Treatment: gastric lavage, appointment of activated carbon, laxatives, symptomatic and supportive therapy. Hemodialysis nyeeffyektivyen.

Dosing and Administration.

Inside - By 60 mg 2 once a day (patients with decreased renal function is 1 time); When the seasonal allergicescom rinite- 120 mg 1 once a day, in chronic idiopathic rash — 180 mg 1 once a day.

Precautions.

During treatment, before allowing the patient to work, require high concentration and speed of psychomotor reactions (driving vehicles, using machinery), check the individual response.

Cooperation