Magnesium hydroxide
When ATH:
A02AA04
Pharmacological action.
The antacid and laxative. Neutralizes free hydrochloric (hydrochloric) acid stomach, reduces the peptic activity of gastric juice. Action magnesium hydroxide is not accompanied by secondary hypersecretion of hydrochloric (salt) acid and changes AAR. Laxative effect comes through 0.5-6 no. Magnesium hydroxide improves peristalsis of intestine.
Pharmacokinetics
The data is not provided
Testimony
Chronic gastritis with normal and elevated secretion in the acute phase; gastric ulcer and duodenal ulcer in the acute phase; discomfort or pain in the epigastric, heartburn after errors in diet, drinking coffee, alcohol, Smoking Area; constipation.
Dosage regimen
As antacid: adults and children over 12 years – by 0.3-1.2 g 4 times / day. Single dose for children 3 to 12 s is 400 mg; the multiplicity of reception – 3-4 times / day. Children over 6 years can be – by 300-600 mg 3-4 times / day.
How to take a laxative before bedtime. In adults and older children 12 s daily dose increased until the desired effect, the average effective dose is 0.8-1.8 g.
Side effect
Maybe: allergic reactions.
Contraindications
Gipermagniemiya, increased sensitivity to magnesium hydroxide.
Cautions
In patients with impaired renal function when using magnesium hydroxide may develop gipermagniemii.
It is used usually in combination with an aluminum antacids to reduce the side effects from the gastrointestinal tract and increase the duration of action.
Drug Interactions
In an application with antacids, containing magnesium, possible to reduce the plasma concentration of fluoroquinolone antimicrobials derivatives, that can reduce their effectiveness.
With simultaneous use of a combination of magnesium hydroxide and aluminum hydroxide with azithromycin may decrease its Cmax plasma.
In an application with glibenclamide, tolbutamide may increase the bioavailability of glibenclamide and tolbutamide.
There are reports of increased absorption dicumarol when applied simultaneously with magnesium hydroxide.
With simultaneous use of a combination of magnesium hydroxide and aluminum hydroxide with diflunizalom decreases its bioavailability.
While the use of iron salts may decrease the absorption of iron.
In an application increases the initial absorption of ibuprofen and flurbiprofen.
In an application may decrease the concentration of indomethacin in plasma. Reduced irritant effect of indomethacin on the gastrointestinal tract.
In an application with captopril may reduce AUC captopril.
With simultaneous use of a combination of magnesium hydroxide and aluminum hydroxide with carbenoxolone may decrease its effectiveness; with lanzoprazolom – possible mild decrease in its bioavailability; penicillamine – reduced absorption from the gastrointestinal tract penicillamine; with sulpiride – may decrease the absorption of sulpiride; prednisone and, apparently, with prednisolone – may reduce the absorption of corticosteroids; with pyrazinamide – possibly slowing, but not the extent of absorption of pyrazinamide; with quinidine – its toxicity may increase due to a significant increase in urinary pH and to reduce the excretion of quinidine; cimetidine or ranitidine – may decrease the absorption of cimetidine and ranitidine.
With simultaneous use of magnesium hydroxide with mefenamic acid increases absorption mefenamic acid; with nitrofurantoin – may reduce the absorption of nitrofurantoin; phenytoin – perhaps a slight decrease in the absorption of phenytoin; chlorpromazine – may decrease the absorption of chlorpromazine; with hlorpropamidom – may increase the absorption of chlorpropamide.
