Ciprogeptadin

When ATH:
R06AX02

Characteristic.

Cyproheptadine hydrochloride is a white or slightly yellowish crystalline powder., soluble in water and chloroform, easily soluble in methanol, sparingly soluble in ethanol and practically insoluble in ether. Molecular weight 350,89.

Pharmacological action.
Antihistamine, antiallergic, antiserotoninovoe.

Application.

Hives (acute, chronic and cold), pollen disease, serum sickness, year-round or seasonal allergic rhinitis, allergic conjunctivitis, angioedema; allergic reactions to receive medicines and contrast media, blood transfusion, insect bites; skin diseases — zudaschie medicine, contact dermatitis, toksikodermiya, neurodermatitis, eczema; headache of vascular origin (migraine), vasomotor rhinitis; anorexia, kaxeksija (during convalescence, chronic diseases), complex therapy of chronic pancreatitis.

Contraindications.

Hypersensitivity, zakrыtougolynaya glaucoma, benign prostatic hyperplasia, urinary retention, piloroduodenalynaya obstruction, stenoziruyushtaya pepticheskaya ulcer, predisposition to edema, concurrent use with MAO inhibitors, elderly patients, pregnancy, lactation, infancy (to 6 Months).

Pregnancy and breast-feeding.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: weakness, sedation and somnolence (often transient), anxiety, headache, dizziness, ataxia, heteroptics.

Cardio-vascular system and blood (hematopoiesis, hemostasis): gipotenziya, tachycardia, gemoliticheskaya anemia, leukopenia, agranulocytosis.

From the digestive tract: dry mouth, nausea, vomiting, diarrhea.

Allergic reactions: rash, angioedema, hives, anaphylaxis, photosensitivity.

Other: weight gain.

Cooperation.

Caffeine reduces the inhibitory effect of cyproheptadine on the CNS; the additive effect can be observed in the combined use of cyproheptadine with ethyl alcohol and other substances, CNS depressants (sedativnыe, hypnotics drugs, anxiolytics). Concomitant use of other drugs cyproheptadine, CNS depressants, It requires constant monitoring of patients and drug withdrawal, if necessary. Combined use of cyproheptadine with fluoxetine and other inhibitors of reverse neuronal serotonin reduces the efficacy of antidepressants. Concomitant use with MAO inhibitors cyproheptadine. MAO inhibitors, and tricyclic antidepressants can prolong and enhance the m-anticholinergic effect of cyproheptadine, and a dampening effect on the central nervous system.

Overdose.

Symptoms: children-midriaz and stiffness pupils, facial flushing, hyperthermia, excitation, anxiety, hallucinations, ataxia, athetosis, convulsions, collapse, coma; adult - confusion, depression, coma, or psychomotor agitation, convulsions; rarely hyperthermia and hyperemia skin.

Treatment: induction of vomiting, appointment of activated charcoal inside, followed by washing the stomach; in the development of life-threatening symptoms of the central nervous system or expressed atropinopodobnykh effects — a solution fizostigmina salicilata; on the grounds is a vasoconstrictor and anti-convulsants, IVL, other resuscitation. Stimulants and analeptic agents are contraindicated.

Dosing and Administration.

Inside, after meal. Adults-on 4 mg 3 once a day; for the treatment of chronic urticaria is 2 mg 3 once a day; When migraines amok- 4 mg dose, in the absence of effect in 30 min — yet 4 mg; for the maintenance therapy — 4 mg 3 once a day; Anorexia — 12 mg three reception; The maximum daily dose - 32 mg. The duration of treatment to increase body weight should not exceed 6 Months. Children from 6 Months before 2 years (with caution in special cases) - To 0,4 mg/kg/day for 3-4 weeks, 2-6 years - 6 mg / day, 6-14 years - 12 mg / day, Anorexia is to 8 mg / day 3 admission. The duration of treatment for anorexia and cachexia no more 3 Months. The maximum daily dose in children 2-6 years- 8 mg, 6-14 years - 16 mg.

Precautions.

The first method is recommended in the evening, postprandial (sedation is characteristic of the start of treatment). Be wary designate children and elderly patients (possible hypersensitivity), patients with a history of bronchial asthma, hyperthyroidism, increased intraocular pressure, hypertension and other diseases of the cardiovascular system.

During the course of treatment can not drink alcohol.

It can be used in conjunction with narcotic analgesics, anxiolytics (under strict medical supervision) Integrated preoperative patients, tk. cyproheptadine potentiates the action of these drugs, while the use and prevents the development of undesirable effects of histamine (hypotension, bronchospasm), released as a result of trauma the body tissues during surgery.

Should not be used during the drivers of vehicles and people, skills relate to the high concentration of attention, especially in the initial, individually determined, treatment period.

Cooperation