Chlorpromazine

When ATH:
N05AA01

Characteristic.

White or white with a faint blue polka crystalline powder. Slightly hygroscopic, dark to light. Very easily soluble in water. Powder and Water solutions darken the light.

Pharmacological action.
Neuroleptic, antipsychotic, sedation, miorelaksiruyuschee, antiemetic.

Application.

In Psychiatry — acute and chronic paranoid and/or hallucinatory State, psychomotor agitation in schizophrenia (hallucinatory-delusional, hebephrenic, catatonic syndromes), maniakalʹnoe Excitation at maniakální-depressivnom psychosis, psychotic disorders in epilepsy, agitated depression (in senile and maniakální-depressivnom psychosis), alcoholic psychosis, as well as others. symptoms of the disease with a productive and exciting. In Neurology is increased muscle tone, torpid pain, persistent insomnia, status epilepticus (the ineffectiveness etc.. preparations). As protivorvotny means, Ménière's disease, anacatharsis pregnant, anticancer drugs in the treatment of, radiation therapy. Anesthesiology-for then and potenzirovania narcosis, when artificial hypothermia (mixtures composed of lytic). In dermatology-zudaschie medicine.

Contraindications.

Hypersensitivity, severe liver or kidney failure, progressive systemic diseases of the brain and spinal cord, coma, brain injury, pronounced inhibition of hematopoiesis, myxedema, decompensated heart defects, active rheumatism, thromboembolism, bronchiectasis (later stages), cholelithiasis and urolithiasis, Acute pyelitis, aggravation of erosive and ulcerative gastrointestinal diseases, pregnancy.

Restrictions apply.

Cholelithiasis and nephrolithiasis, Acute pyelitis, active rheumatism, gastric ulcer or duodenal ulcer (appointment inside).

Side effects.

Local: by ingestion solution on the skin and mucous tissue irritation —; When the/m introduction-infiltrates, with a / in the introduction - phlebitis. General: in the long-term use-neirolepticeski syndrome (parkinsonizm, akathisia, indifference, delayed reaction), depression; the on/in the introduction-gipotenzia; ingestion-dyspeptic syndrome (nausea, vomiting, constipation). Rarely is jaundice, agranulocytosis, leather pigmentation, cataract; allergic reactions (rash, swelling, photosensitivity).

Cooperation.

Antacids reduce the absorption and cimetidine. It enhances the effect of hypnotics, drugs, analgesics, local anesthetics, anticonvulsants, reduces-cardiac glycosides. When combined with M-holinoblokatorami observed summation holinoliticheskih effects. Estrogens increase the antipsychotic properties.

Overdose.

Manifested neuroleptic syndrome, persistent hypotension, hypothermia, coma, later toxic hepatitis.

Dosing and Administration.

Adults, inside -on 25-600 mg/day, The maximum single dose - 300 mg. / M - To 1 g / day, The maximum single dose - 150 mg. B / - To 250 mg / day, The maximum single dose - 100 mg. Children — inside 1 mg / kg body weight per day.

Precautions.

Prolonged treatment is necessary to control the cellular composition of blood, prothrombin index, liver and renal function. After injecting patients preferably within 1-1, 5 h in a horizontal position.

Cooperation