Flufenazin

When ATH:
N05AB02

Characteristic.

Piperazine phenothiazine. The white crystalline powder, almost odorless. Soluble in water, moderate - in alcohol and ether, poorly - in chloroform and acetone.

Pharmacological action.
Neuroleptic, antipsychotic.

Application.

Schizophrenia (all forms) and psychosis (acute and chronic, incl. paranoid), especially taking place against a background of depressive-hypochondriac and-stuporous catatonic, apathy and indifference, including relief of aggression and psychomotor agitation; neurotic state, accompanied by fear, tension.

Contraindications.

Hypersensitivity (incl. other phenothiazines), organic disease and brain injury, acute depression, pronounced CNS depression, coma, liver and heart failure, blood disease, pregnancy, lactation, Children age - up 12 years (fluphenazine decanoate).

Restrictions apply.

Epilepsy, epileptic seizures in history, cardiovascular diseases (incl. mitral valve insufficiency), prostatauxe, zakrыtougolynaya glaucoma, pheochromocytoma, Parkinson's disease, renal failure.

Side effects.

From the nervous system and sensory organs: drowsiness, lethargy, extrapyramidal disorder (incl. psevdoparkinsonizm, dystonia, pozdnyaya dyskinesia, akathisia, oculogyric crises, opisthotonus, hyperreflexia), headache, pigmentnaya retinopathy, deposits in the lens and cornea; fluphenazine decanoate for, Besides, - Muscle rigidity with hyperthermia.

Cardio-vascular system and blood (hematopoiesis, hemostasis): decrease in blood pressure, tachycardia, leukopenia, agranulocytosis, eozinofilija, anemia, pancytopenia.

From the digestive tract: nausea, constipation, decreased appetite, excessive salivation / dry mouth, cholestatic jaundice.

Allergic reactions: skin rash, hives, dermatitis.

Other: polyuria, urinary retention, evaporated, galactorrhea, dysmenorrhoea, gynecomastia in men, photosensitivity, dermatomelasma, weight gain, neuroleptic malignant syndrome.

Dosing and Administration.

Inside, / m (deep in the muscle). Inside the dose adjusted, depending on the patient and its sensitivity to the drug. The treatment is initiated with smaller dosages, gradually increasing them to optimum effect. Adults - 1-5 mg / day, if necessary (in hospital) - 10 mg / day. The daily dose take in 3-4 hours. When states of anxiety, tension and fear - at a dose of 1-3 mg. Elderly patients are administered in smaller doses. Children dose reduced in accordance with age. V / m - 12.5-25 mg every 2-4 weeks, may increase the dose to 50-100 mg.

Precautions.

Be wary combine with hypertensive drugs in elderly patients and apply at working at elevated temperatures, having contact with phosphorus insecticides. When long-term therapy is necessary to monitor the number of white blood cells, carrying out liver function tests.

The development of tardive dyskinesia is more likely in the elderly, particularly in elderly women. The risk of developing the syndrome and the likelihood of its irreversibility increases with increasing duration of treatment and total cumulative dose of antipsychotic. If signs or symptoms of tardive dyskinesia should consider stopping treatment fluphenazine (However, some patients may need to continue treatment, despite the presence of the syndrome).

When symptoms of neuroleptic malignant syndrome, the use of drugs should be stopped immediately and conduct an intensive symptomatic treatment.

Be aware of the possibility of liver damage, development of pigment retinopathy, deposits in the lens and cornea and irreversible dyskinesia during long-term therapy.

During treatment, should not engage in activities, requiring greater attention, rapid mental and motor responses.

Fluphenazine decanoate is not recommended for the elderly.