Buspirone

When ATH:
N05BE01

Characteristic.

Non-benzodiazepine anxiolytic structure. Буспирона гидрохлорид — белый кристаллический порошок. It is soluble in water. Molecular weight 422,0.

Pharmacological action.
Anxiolytic.

Application.

Generalized anxiety disorder, panic disorder, vegetative dystonia syndrome, alcohol withdrawal syndrome (adjuvant therapy), depression (adjuvant therapy).

Contraindications.

Hypersensitivity, severe renal dysfunction and liver, glaucoma, myasthenia gravis, pregnancy, lactation.

Restrictions apply.

Age to 18 years (Safety and efficacy have not been determined).

Pregnancy and breast-feeding.

When pregnancy is used only when necessary.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: dizziness (12%), drowsiness (10%), headache (6%), nervousness (5%), fatigue (4%), sleep disturbance (3%), reduced ability to concentrate (2%); extrapyramidal disorder (rarely); ≤2% — нечеткость зрения, confusion or depression, weakness, numbness; ≤1% — неврологические симптомы (muscle weakness, pricking, pain or weakness in the hands or feet, uncontrolled movements of body).

Cardio-vascular system and blood (hematopoiesis, hemostasis): ≤1% — тахикардия/сильное сердцебиение.

From the digestive tract: nausea (8%), dry mouth (3%), diarrhea (2%); ≤1% — рвота, constipation; loss of appetite.

Other: ≤1% — миалгия, spasms, muscle stiffness or spasms, rash, Sweating.

Cooperation.

In combination with MAO inhibitors may develop hypertensive crisis.

Overdose.

Symptoms: nausea, vomiting, etc.. gastrointestinal disorders, dizziness, mioz, drowsiness.

Treatment: gastric lavage, appointment of activated carbon, simptomaticheskaya therapy. Dialysis nyeeffyektivyen.

Dosing and Administration.

Inside. Рекомендуемая начальная доза — по 5 mg 3 once a day, при необходимости ее можно увеличивать на 5 мг каждые 2–3 дня. Средняя суточная доза — 20–30 мг. The maximum single dose - 30 mg, daily - 60 mg.

Precautions.

With caution used in conjunction with neuroleptics, antidepressants, cardiac glycosides, antihypertensive and antidiabetic agents, oral contraceptives. In renal and liver failure mild to moderate severity, cirrhosis designate smaller doses and under strict medical supervision. The treatment should be deleted alcohol. At the beginning of treatment used with caution during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cautions.

It should be taken into account, that anxiety or stress, associated with daily stress, usually does not require treatment with anxiolytics.