Selegiline

When ATH:
N04BD01

Characteristic.

Selegilina hydrochloride is a white or almost white crystalline powder, soluble in water, xloroforme, methanol. Molecular weight 223,75.

Pharmacological action.
Antiparkinsonian.

Application.

Parkinson's Disease, symptomatic Parkinsonism.

Contraindications.

Hypersensitivity, extrapyramidal disorder, not associated with a deficiency of dopamine (essential tremor, Huntington Gentingtona); pregnancy, lactation.

Restrictions apply.

Peptic ulcer and duodenal, uncontrolled hypertension, severe angina pectoris, psychosis, glaucoma, thyrotoxicosis, pheochromocytoma, prostatic hyperplasia (with the presence of residual urine), Age to 18 years.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

From the nervous system and sensory organs: anxiety, fatiguability, dizziness, headache, drowsiness or insomnia, depression, hallucinations, confusion, speech disorder, gait, supraorbitale pain, violation of visual acuity, diplopia.

Cardio-vascular system and blood (hematopoiesis, hemostasis): arrhythmia, orthostatic reactions, increased blood pressure, swelling.

From the digestive tract: nausea and vomiting, decreased appetite, dry mouth, dyspepsia, constipation or diarrhea, exacerbation of peptic ulcer disease, increase in liver transaminases.

Other: disorders of sexual function, urinary retention, exacerbation of asthma, dizurija, hyperhidrosis, photosensitivity, skin rash.

Cooperation.

Potenziruet effects of levodopa. Joint application with tricyclic antidepressants, MAO inhibitors and fluoksetinom can cause toxic reactions-hyperthermia, rigidity, myoclonus, coma.

Overdose.

Symptoms: Perhaps the "cheese syndrome" (ingibiruet MAO of all types) as gipertenziveh reactions and exacerbation of ISCHEMIC HEART DISEASE after eating, containing tyramine (cheese, coffee, etc.), excitation.

Treatment: induction of vomiting, gastric lavage, activated carbon; in initiating and fits in/with the introduction of diazepam; simptomaticheskaya therapy.

Dosing and Administration.

Inside, 10 mg / day 2 receiving at 5 mg for breakfast and lunch. Usually, used in conjunction with combinations levodopa/carbidopa. During long-term therapy may reduce the dose of levodopa.

Precautions.

With caution is prescribed for kidney failure, pathology of the cardiovascular system, gastric ulcer and duodenal ulcer, glaucoma, diseases of the thyroid and adrenal glands. Reduces the speed of reaction and attention, as it is necessary to inform drivers of vehicles and working with potentially dangerous machinery. It should be borne in mind in respect of drug after-effect MAO — up to 5-7 days in the appointment adrenomimetikov. Selegilin may be nominated through 5 weeks after fluoksetina.