Klozapyn

When ATH:
N05AH02

Characteristic.

Greenish-yellow crystalline powder. Practically insoluble in water, it is soluble in alcohol.

Pharmacological action.
Neuroleptic, antipsychotic, sedation, miorelaksiruyuschee.

Application.

Acute and chronic forms of schizophrenia, mania, affective insanity, various psychotic states, psychomotor agitation in psychosis, aggressiveness, sleep disorders.

Contraindications.

Hypersensitivity, diseases of the hematopoietic system, alcoholic and toxic psychoses, myasthenia, pregnancy, lactation.

Restrictions apply.

Severe liver disease, kidney and cardiovascular system, increased susceptibility to seizures, epilepsy, zakrыtougolynaya glaucoma, prostatauxe, bowel atony, intercurrent illness with fever syndrome.

Side effects.

Muscular weakness, drowsiness, confusion, dry mouth, sometimes hypersalivation, Parez akkomodacii, tachycardia, decrease in blood pressure and dizziness (orthostatic hypotension), flattening of the T wave on the ECG, Hyperthermia central origin, exacerbation of chronic or latent infection foci (tonsillitis, periostitis, pyoderma), granulocytopenia (vploty to agranulocytosis).

Cooperation.

Do effect sedatives, Narcotic, analgesics and hypnotics, alcohol, effects on the central nervous system antihistamines, Weakens - levodopa (and other Dofaminomimetiki). The absorption from the gut is getting worse while taking the gel structure antacids and cholestyramine.

Dosing and Administration.

Inside (granules from a disposable package are diluted in 5-10 ml of water), After eating - 50-200 mg 2-3 times a day, daily dose for adults: initial - 150-300 mg, average - 200-400 mg, Higher - 600 mg. For supporting therapy and outpatient patients, 25-200 mg are prescribed for 25-200 mg. A single dose for children 6-8 years old - 5-10 mg, 8–15 years - 10–20 mg, Daily dose for children 6–8 years old - 15-30 mg, 8–15 years - 30-60 mg, it is divided into 2-3 doses; The highest daily dose for children - 100 mg.

Precautions.

During treatment should not drive vehicles or perform work, requiring increased attention and rapid mental and motor responses. A periodic (first weekly, and then every 3-4 months) Control of the blood picture - with the appearance of granulocytopenia, treatment is immediately terminated.