Propofol

When ATH:
N01AX10

Pharmacological action.
Anesthesia, sedation.

Application.

Induction and maintenance of general anesthesia, sedation during mechanical ventilation.

Contraindications.

Hypersensitivity.

Restrictions to the use of.

Natural infancy (to 3 years), lactation.

Side effects.

Short-term cessation of breathing, breathlessness; rarely convulsions, opisthotonus, pulmonary edema; в период пробуждения — головная боль, nausea, vomiting, postoperative fever (rarely).

Cooperation.

Compatible with preparations for spinal and epidural anesthesia, medicine, used in premedication, with muscle relaxants and analgesics.

Overdose.

Manifested oppression of cardiac activity and respiration. Treatment is symptomatic for background ventilation (oxygen), maintaining hemodynamic (IV fluids and vasopressors).

Dosing and Administration.

B /. Для вводной анестезии взрослым вводят по 40 mg every 10 from (before clinical signs of anesthesia), older children 8 years - 2,5 mg / kg. For maintenance of anesthesia using continuous infusion or, or repeated bolus. Dose picked individually, адекватная анестезия достигается при введении со скоростью 4–12 мг/кг/ч, детям — 9–15 мг/кг/ч. To provide sedation in intensive care patients, on mechanical ventilation, в/в инфузируют со скоростью 0,3–4 мг/кг/ч.

Precautions.

In cases, when there is a possibility of side effects, associated with the activation of the vagus nerve, it is advisable before induction of anesthesia in / in a cholinolytic. Do not use in obstetric practice, tk. Propofol crosses the placenta and can cause neonatal depression (may use in the I trimester during operations abortion).

The risk of pain along the vein may be significantly reduced during infusion through a large vein diameter or simultaneous introduction of lidocaine. The injection can be done only by trained personnel with the possibility of immediate use of mechanical ventilation, -therapy, resuscitation in full.

Cooperation