Propofol

When ATH:
N01AX10

Pharmacological action.
Anesthesia, sedation.

Application.

Induction and maintenance of general anesthesia, sedation during mechanical ventilation.

Contraindications.

Hypersensitivity.

Restrictions to the use of.

Natural infancy (to 3 years), lactation.

Side effects.

Short-term cessation of breathing, breathlessness; rarely convulsions, opisthotonus, pulmonary edema; during the period of awakening - headache, nausea, vomiting, postoperative fever (rarely).

Cooperation.

Compatible with preparations for spinal and epidural anesthesia, medicine, used in premedication, with muscle relaxants and analgesics.

Overdose.

Manifested oppression of cardiac activity and respiration. Treatment is symptomatic for background ventilation (oxygen), maintaining hemodynamic (IV fluids and vasopressors).

Dosing and Administration.

B /. For introductory anesthesia, adults are introduced by 40 mg every 10 from (before clinical signs of anesthesia), older children 8 years - 2,5 mg / kg. For maintenance of anesthesia using continuous infusion or, or repeated bolus. Dose picked individually, Adequate anesthesia is achieved by administration at a speed of 4–12 mg/kg/h, children - 9-15 mg/kg/h. To provide sedation in intensive care patients, on mechanical ventilation, V/V is infused at a speed of 0.3–4 mg/kg/h.

Precautions.

In cases, when there is a possibility of side effects, associated with the activation of the vagus nerve, it is advisable before induction of anesthesia in / in a cholinolytic. Do not use in obstetric practice, tk. Propofol crosses the placenta and can cause neonatal depression (may use in the I trimester during operations abortion).

The risk of pain along the vein may be significantly reduced during infusion through a large vein diameter or simultaneous introduction of lidocaine. The injection can be done only by trained personnel with the possibility of immediate use of mechanical ventilation, -therapy, resuscitation in full.

Cooperation

Active substance	Description of interaction
Azelastin	FMR: synergism. Do effect; in postanesthesia period more significantly reduced the rate of psychomotor reactions.
Alprazolam	FMR: synergism. Enhances anesthetic and sedation (mutually) effects; the combined appointment of possible distinct reduction in systolic, diastolic and mean arterial pressure and cardiac output.
Buprenorphine	FMR: synergism. Strengthens (mutually) anesthetic and sedation; combined use may cause a decrease in cardiac output and blood pressure.
Vancomycin	FMR. Against the background of propofol increases the likelihood of erythema, histamine tides and anaphylactic shock.
Haloperidol	FMR: synergism. Strengthens (mutually) CNS depression.
Halothane	FMR: synergism. Strengthens (mutually) effects. Against the background of increased risk of propofol kardiodepressii.
Diazepam	FMR: synergism. Enhances anesthetic and sedation (mutually) effects; the combined appointment of possible distinct reduction in systolic, diastolic and mean arterial pressure and cardiac output.
Diltiazem	FMR: synergism. Increases related to anesthesia, depression of cardiac contractility, conduction, automatism and vasodilatation.
Droperidol	FMR: synergism. Strengthens (mutually) anesthetic and sedation. Against the background of propofol increased likelihood of decreased cardiac output and blood pressure.
Zolpidem	FMR: synergism. Strengthens (mutually) effect.
Izofluran	FMR: synergism. Strengthens (mutually) effect.
Clonazepam	FMR: synergism. Strengthens (mutually) effects.
Codeine	FMR: synergism. Strengthens (mutually) anesthetic and sedation; combined use may cause a decrease in cardiac output and blood pressure.
Lorazepam	FMR: synergism. Strengthens (mutually) effects.
Metoclopramide	FMR. Do effect. Against the background of propofol attenuated stimulation of motor activity of the digestive tract.
Midazolam	FMR: synergism. Strengthens (mutually) effect; the combined use of increased likelihood of decreased cardiac output and blood pressure.
Morphine sulfate	FMR: synergism. Strengthens (mutually) anesthetic and sedation; combined use may cause a decrease in cardiac output and blood pressure.
Oxazepam	FMR: synergism. Strengthens (mutually) effects; the combined appointment of possible distinct reduction in systolic, diastolic and mean arterial pressure and cardiac output.
Oxybutynin	FMR: synergism. Against the background of propofol (postanesthesia period) increasing hypnotic effect.
Pramipexole	FMR: synergism. Strengthens (mutually) sedation; In sharing caution: increasing the risk of side effects from the CNS.
Topiramate	FMR: synergism. Do effect.
Phenobarbital	FMR: synergism. Enhances anesthetic and sedation (mutually) effects; the combined appointment increases the likelihood of reduction in cardiac output and blood pressure.
Fentanyl	FMR: synergism. Increases (mutually) anesthetic and sedation; combined use can cause severe bradycardia, decreased cardiac output and blood pressure.
Xlordiazepoksid	FMR: synergism. Strengthens (mutually) effects.