Vancomycin (When ATH A07AA09)

When ATH:
A07AA09

Characteristic.

Antibiotic group glycopeptides.

It is soluble in water, sparingly in methanol, weakly-higher alcohols, acetone and ether.

Pharmacological action.
Antibacterial, bactericide.

Application.

Severe infectious and inflammatory diseases, caused by susceptible pathogens to vancomycin (and the ineffectiveness of penicillin intolerance, cephalosporins and other antibiotics): sepsis, endokardit, pneumonia, lung abscess, osteomyelitis, infections of skin and skin structure, psevdomembranoznыy colitis, caused Clostridium difficile, enterocolitis, meningitis.

Contraindications.

Hypersensitivity, neuritis of the auditory nerve, pregnancy (I trimester).

Restrictions apply.

Severe kidney damage, hearing loss, pregnancy (II and III trimester), lactation.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

Nausea, vomiting, bitter taste in the mouth, chills, itching, hives, Syndrome Stevens - Johnson. After the on/in a throm-, vasculitis, fever, neutropenia, eozinofilija, thrombocytopenia, sometimes anaphylactoidnye reaction. With the rapid on / in a possible burning sensation, reddening of the upper body (Syndrome of "red neck"), pain and muscle spasms in the back and chest, hypotension, dizziness, noise in ears. In rare cases, UTO- and nephrotoxicity (hearing loss including deafness, renal failure, azotemia, interstitial nephritis).

Cooperation.

When combined with aminoglycosides, амфотерицином B, bacitracin, loop diuretics, cisplatin, cyclosporine, polymyxins increase the risk of hearing loss and kidney damage. Kolestiramin reduces efficiency. Joint application with the general anesthetics can lead to the development of erythema, histamine tides and anaphylactic shock.

Overdose.

It is characterized by increased severity of side effects.

Treatment: symptomatic combined with hemoperfusion and hemofiltration.

Dosing and Administration.

B /, drop. Adults-on 0,5 g every 6 or h 1 g every 12 no. To avoid kollaptoidnyh reactions infusion duration of not less than 60 m. Children appoint daily dose 40 mg / kg, Each dose should be administered at least 60 m. In patients with impaired renal excretory function, reduce the dose based on the values ​​Cl creatinine.

If pseudomembranous colitis appointed interior in the form of a solution: adults — in a daily dose of 0.5-2 g (3-4 reception), Children - 40 mg / kg (3-4 reception).

Cooperation