Clavulanic acid

When ATH:
J01CR

Pharmacological action

Beta-lactamase inhibitor. Produced by Streptomyces clavuligerus cultures. Beta-lactam has the structure, similar to the structure of the nucleus of penicillin molecule, Unlike which comprises oxazolidine ring instead closed thiazolidine ring. It has weak antimicrobial activity. It is a beta-lactamase inhibitor, produced by Gram-negative bacteria, including Haemophilus ducreyi, Haemophilus influenzae, Neisseria gonorrhoeae, Moraxella (Branham) catarrhalis, Bacteroides fragilis and some Enterobacter spp. Besides,Clavulanic acid inhibits beta-lactamases Staphylococcus aureus. It has the ability to penetrate the bacterial cell wall and cause inactivation of enzyme and which are inside the cell and on its boundary. It acts as a competitive and often irreversible inhibitor.

Testimony

In combination with amoxicillin or Tikarcillinom Clavulanic acid is used to treat infectious and inflammatory diseases, caused by susceptible microorganisms, a combination.

Dosage regimen

Individual, depending on the evidence, the patient's age, the dosage form.

Side effect

Cardio-vascular system: rarely if swallowed – dyspepsia, abnormal liver function, hepatitis, cholestatic jaundice; in some cases – psevdomembranoznыy colitis.

Allergic reactions: in some cases – erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, and urticaria, angioedema, anaphylactic shock.

Other: in some cases – candidiasis.

Contraindications

Hypersensitivity to clavulanic acid.

Pregnancy and breast-feeding

In combination with amoxicillin or ticarcillin use during pregnancy is possible only if there is evidence of life, otherwise – not recommended.

Cautions

Intravenous should be used with caution in patients with severe hepatic impairment.

When urticaria or erythematous rash treatment should be discontinued.