Tikarцillin

When ATH:
J01CR03

Pharmacological action

Broad-spectrum antibiotic, It represents karboksipenitsillin broad spectrum antibacterial activity.

Active against a broad spectrum of microorganisms (except for strains, продуцирующих b-лактамазы), incl. Aerobic gram-positive bacteria: Staphylococcus spp. (включая Staphylococcus aureus и Staphylococcus epidermidis), Streptococcus spp. (включая Streptococcus faecalis); anaerobic gram-positive bacteria: Peptococcus spp., Peptostreptococcus spp., Сlostridium spp., Eubacterium spp.; Aerobic Gram-negative bacteria: Escherichia coli, Haemophilus spp. (включая Haemophilus influenzae), Branhamella catarrhalis, Klebsiella spp. (включая Klebsiella pneumoniae), Enterobacter spp., Proteus spp. (including indole-positive strains), Morganella morganii, Rettgeri Providence, Providence stuartii, Pseudomonas spp. (including Pseudomonas aeruginosa, and Stenotrophomonas maltophilia), Serratia spp. (including Serratia marcescens), Citrobacter spp., Acinetobacter spp., Yersinia enterocolitica, Salmonella spp., Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic gram-negative bacteria: Bacteroides spp. (including Bacteroides fragilis), Fusobacterium spp., Veillonella spp.

Use in combination with clavulanic acid (ингибитор b-лактамаз) It extends the range of the antimicrobial activity of ticarcillin.

Testimony

Severe infectious and inflammatory diseases, caused by susceptible microorganisms (in combination with clavulanic acid): sepsis, septicemia; bacteraemia; intra-abdominal infections (incl. peritonitis); postoperative infections; gynecological infections (incl. endometritis); bone and joint infections; infections of skin and soft tissue; respiratory tract infections; severe or complicated infections of the urinary tract (incl. pyelonephritis); infection of upper respiratory tract; or suspected infection in patients with compromised or suppressed immune system.

Dosage regimen

Individual, depending on the evidence, the patient's age, renal function.

Side effect

Allergic reactions: skin rash, itch, hives, anaphylactic reactions; rarely – erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

From the digestive system: nausea, vomiting, diarrhea, a moderate increase in AST and / or ALT; rarely – psevdomembranoznыy colitis; rarely – hepatitis, cholestatic jaundice.

CNS: rarely - seizures (especially in patients with impaired renal function and with the appointment of the drug in high doses).

From the hematopoietic system: rarely – thrombocytopenia, leukopenia, eozinofilija, reduction of hemoglobin and signs of bleeding.

Local reactions: tromboflebit.

Other: rarely – kaliopenia.

Contraindications

Premature babies with impaired renal function, Hypersensitivity to ticarcillin, beta-lactam antibiotics (eg, to penicillins and cephalosporins) history.

Pregnancy and lactation

If necessary, use during pregnancy and lactation should carefully weigh the potential benefits of therapy to the mother and the potential risk to the fetus.

Cautions

When any hypersensitivity reactions treatment should be discontinued.

Be wary appoint patients with severely impaired hepatic function.

Bleeding, which are rarely observed in the treatment of beta-lactam antibiotics (incl. penicillins, cephalosporins and carbapenems), They may be associated with bleeding disorders, in particular indicators such as clotting times, platelet aggregation and prothrombin time, and are more likely in patients with impaired renal function. If signs of bleeding antibiotic therapy should be discontinued and appropriate therapy appoint.

Ticarcillin not apply in preterm neonates with impaired renal function.

Drug Interactions

Probenecid reduces the secretion of ticarcillin renal tubules. Concomitant use with probenecid leads to slower renal excretion ticarcillin.

Ticarcillin shows synergy with aminoglycosides against a number of microorganisms (incl. Pseudomonas spp.).