Gidroksizin

When ATH:
N05BB01

Characteristic.

Diphenylmethane derivatives. Hydroxyzine hydrochloride - a white powder, without smell. Very soluble in water.

Pharmacological action.
Sedation, anxiolytic.

Application.

Relief of anxiety, psychomotor agitation, internal stress, neurological irritability, mental (generalized anxiety and disturbance adaptation) and somatic diseases; alcohol withdrawal syndrome; premedication and postoperative period (in a combination therapy); itch (simptomaticheskaya therapy).

Contraindications.

Hypersensitivity, incl. to cetirizine, aminophylline or ethylenediamine; porphyria, pregnancy, during labor, lactation.

Restrictions apply.

Glaucoma, prostatic hypertrophy with clinical manifestations (incl. strangury, constipation), myasthenia, dementia, propensity to seizures, kidney and / or liver failure.

Pregnancy and breast-feeding.

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: drowsiness, weakness (in the early days of admission), headache, dizziness.

Other: increased perspiration, tachycardia, nausea, allergic reactions, dry mouth, urinary retention, constipation, ccomodation eye.

Cooperation.

Dampening effect on the central nervous system narcotic analgesics, ʙarʙituratov, trankvilizatorov, hypnotics (It requires individual titration), alcohol. It prevents the development of the pressor effect of epinephrine, anticonvulsant activity of phenytoin, betahistine action and cholinesterase blockers. Weakens side effects (from the gastrointestinal tract) theophylline and beta₂-adrenomimetikov).

Overdose.

Symptoms: gipersedatsiya, tremor, convulsions, hallucinations, confusion, low blood pressure, nausea, vomiting.

Treatment: induction of vomiting (in the absence of spontaneous), gastric lavage, General supportive measures, incl. monitoring of vital body functions. If hypotension - a norepinephrine (but not epinephrine). There is no specific antidote. Hemodialysis nyeeffyektivyen.

Dosing and Administration.

Inside, / m. Adults: in general practice - 25-100 mg / day in divided doses, in psychiatry - up 300 mg / day. The usual duration of treatment - 4 Sun. In Anesthesiology: / m, adults - 100-200 mg / day, for sedation - 50-200 mg.

Children designate depending on the age and body weight.

In simultaneous treatment facilities, CNS depressants, or holinoblokatorami, need a dose adjustment. The dose should be reduced in elderly patients (treatment is initiated with half the therapeutic dose), in renal and liver failure.

Precautions.

If such side effects like drowsiness and weakness do not disappear after several days of treatment, necessary to reduce the dose of. Avoid joint appointment with MAO inhibitors. To use caution in patients, prone to arrhythmia or receiving antiarrhythmic drugs, and in patients, predisposed to convulsive reactions.

During treatment should avoid drinking alcohol. When the need for allergy tests receiving hydroxyzine should be discontinued for 5 days prior to the study. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cautions.

The injectable form of hydroxyzine are only for i / m injection and should not be entered in /, B / A s / c. When i / m administration must ensure, that the needle does not hit in any vessel. When administered to the skin the drug may cause tissue damage.

Cooperation