Gidroksizin

When ATH:
N05BB01

Characteristic.

Diphenylmethane derivatives. Hydroxyzine hydrochloride - a white powder, without smell. Very soluble in water.

Pharmacological action.
Sedation, anxiolytic.

Application.

Relief of anxiety, psychomotor agitation, internal stress, neurological irritability, mental (generalized anxiety and disturbance adaptation) and somatic diseases; alcohol withdrawal syndrome; premedication and postoperative period (in a combination therapy); itch (simptomaticheskaya therapy).

Contraindications.

Hypersensitivity, incl. to cetirizine, aminophylline or ethylenediamine; porphyria, pregnancy, during labor, lactation.

Restrictions apply.

Glaucoma, prostatic hypertrophy with clinical manifestations (incl. strangury, constipation), myasthenia, dementia, propensity to seizures, kidney and / or liver failure.

Pregnancy and breast-feeding.

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: drowsiness, weakness (in the early days of admission), headache, dizziness.

Other: increased perspiration, tachycardia, nausea, allergic reactions, dry mouth, urinary retention, constipation, ccomodation eye.

Cooperation.

Dampening effect on the central nervous system narcotic analgesics, ʙarʙituratov, trankvilizatorov, hypnotics (It requires individual titration), alcohol. It prevents the development of the pressor effect of epinephrine, anticonvulsant activity of phenytoin, betahistine action and cholinesterase blockers. Weakens side effects (from the gastrointestinal tract) theophylline and beta₂-adrenomimetikov).

Overdose.

Symptoms: gipersedatsiya, tremor, convulsions, hallucinations, confusion, low blood pressure, nausea, vomiting.

Treatment: induction of vomiting (in the absence of spontaneous), gastric lavage, General supportive measures, incl. monitoring of vital body functions. If hypotension - a norepinephrine (but not epinephrine). There is no specific antidote. Hemodialysis nyeeffyektivyen.

Dosing and Administration.

Inside, / m. Adults: in general practice - 25-100 mg / day in divided doses, in psychiatry - up 300 mg / day. The usual duration of treatment - 4 Sun. In Anesthesiology: / m, adults - 100-200 mg / day, for sedation - 50-200 mg.

Children designate depending on the age and body weight.

In simultaneous treatment facilities, CNS depressants, or holinoblokatorami, need a dose adjustment. The dose should be reduced in elderly patients (treatment is initiated with half the therapeutic dose), in renal and liver failure.

Precautions.

If such side effects like drowsiness and weakness do not disappear after several days of treatment, necessary to reduce the dose of. Avoid joint appointment with MAO inhibitors. To use caution in patients, prone to arrhythmia or receiving antiarrhythmic drugs, and in patients, predisposed to convulsive reactions.

During treatment should avoid drinking alcohol. When the need for allergy tests receiving hydroxyzine should be discontinued for 5 days prior to the study. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cautions.

The injectable form of hydroxyzine are only for i / m injection and should not be entered in /, B / A s / c. When i / m administration must ensure, that the needle does not hit in any vessel. When administered to the skin the drug may cause tissue damage.

Cooperation

Active substance	Description of interaction
Azelastin	FMR: synergism. Strengthens (mutually) effect; reduced the rate of psychomotor reactions and amplified deprimatsiya.
Alprazolam	FMR: synergism. Strengthens (mutually) CNS depression; against the backdrop of the / m of hydroxyzine dose of alprazolam should be reduced to 50% - The probability of severe, even fatal, complications.
Betagistin	FMR: antagonizm. Against the background of the effect of hydroxyzine is weakened.
Buprenorphine	FMR: synergism. Strengthens (mutually) CNS depression. Against the background of the / m to reduce the dose of hydroxyzine 50% - Possible cardiac arrest and death.
Buspirone	FMR: synergism. Strengthens (mutually) effect; with a joint appointment in the dose should be reduced 50% - The probability of severe, even fatal, complications.
Haloperidol	FMR: synergism. Strengthens (mutually) CNS depression.
Diazepam	FMR: synergism. Strengthens (mutually) CNS depression; while the appointment of the dose should be reduce to 50% - There is a risk of severe, even fatal, complications.
Droperidol	FMR: synergism. Strengthens (mutually) CNS depression; the combined use of in order to avoid severe complications in the lower dose 50%.
Zolpidem	FMR: synergism. Strengthens (mutually) effect.
Izofluran	FMR: synergism. Enhances effects deprimiruyuschie; against the backdrop of hydroxyzine, especially when i / m administration, require smaller doses of anesthetic agents - likely profound CNS depression.
Quetiapine	FMR: synergism. Strengthens (mutually) CNS depression; with a joint appointment in connection with an increased risk of serious complications in the lower dose 50%.
Ketamine	FMR: synergism. Against the backdrop of intensified hydroxyzine deprimiruyuschie effect and require lower doses of anesthetic agents (in order to avoid severe complications).
Klozapyn	FMR: synergism. Strengthens (mutually) effect; with a joint appointment increases the likelihood of developing serious adverse events, and the dose is reduced by 50%.
Clonazepam	FMR: synergism. Strengthens (mutually) effects.
Codeine	FMR: synergism. Strengthens (mutually) deprimatsiyu; with a joint appointment at the lower dose 50% due to the possibility of severe complications (cardiac arrest and death).
Lorazepam	FMR: synergism. Strengthens (mutually) CNS depression.
Midazolam	FMR: synergism. Enhances effects deprimiruyuschie; with a joint appointment dose can be reduced by 50%.
Morphine sulfate	FMR: synergism. Strengthens (mutually) deprimatsiyu; with a joint appointment at the lower dose 50% due to the possibility of severe complications (cardiac arrest and death).
Oxazepam	FMR: synergism. Strengthens (mutually) effects; the combined use of the dose should be reduced to 50% - The probability of severe, even fatal, complications.
Olanzapine	FMR: synergism. Strengthens (mutually) effect; with a joint appointment at the lower dose 50% - High risk of severe complications.
Perfenazyn	FMR: synergism. Strengthens (mutually) effect; with a joint appointment at the lower dose 50% - High risk of severe complications.
Pramipexole	FMR: synergism. Against the background of hydroxyzine may increase sedation (drowsiness); In sharing caution.
Prokaynamyd	Against the background of hydroxyzine (especially large doses) amplified ECG changes (QT interval extension) and increases the risk of cardiac disorders (describes cases of sudden death).
Promethazine	FMR: synergism. Strengthens (mutually) effect; the combined use of the dose should be reduced to 50% - The probability of severe (even fatal) complications.
Propofol	FMR: synergism. Against the backdrop of intensified hydroxyzine deprimiruyuschie anesthetic effect and requires a smaller dose.
Risperidone	FMR: synergism. Strengthens (mutually) effect.
Theophylline	FMR. Against the background of Hydroxyzine reduces the effect on the gastrointestinal tract.
Tioridazin	FMR: synergism. Strengthens (mutually) effect. Against the background of hydroxyzine, in large doses causes a shift in the ECG (QT interval extension), significantly increases the likelihood of cardiac disorders (aritmii), can even cause sudden death.
Topiramate	FMR: synergism. Strengthens (mutually) CNS depression.
Trifluoperazine	FMR: synergism. Strengthens (mutually) effect; with a joint appointment at the lower dose 50% - There is a risk of severe, even fatal, complications.
Phenobarbital	FMR: synergism. Strengthens (mutually) deprimiruyuschie effect; with a joint appointment at the lower dose 50%.
Fentanyl	FMR: synergism. Strengthens (mutually) deprimatsiyu; with a joint appointment at the lower dose 50% due to the possibility of severe complications (cardiac arrest and death).
Flufenazin	FMR: synergism. Strengthens (mutually) effect; with a joint appointment at the lower dose 50% - There is a risk of severe, even fatal, complications.
Quinidine	Against the background of hydroxyzine (especially large doses) amplified ECG changes (QT interval extension) and increases the risk of cardiac disorders (describes cases of sudden death).
Xlordiazepoksid	FMR: synergism. Strengthens (mutually) effects.
Chlorpromazine	FMR: synergism. Strengthens (mutually) effect; with a joint appointment at the lower dose 50% - There is a risk of severe, even fatal, complications.
Epinephrine	FMR: antagonizm. Against the background of weakened pressor effect of hydroxyzine.
Ethanol	FMR: synergism. Strengthens (mutually) deprimiruyuschie effect, at the time of treatment should abandon spirits.