Cetirizine

When ATH:
R06AE07

Characteristic.

The piperazine derivative. Cetirizine hydrochloride - a white crystalline powder, soluble in water.

Pharmacological action.
Antihistamine, antiallergic.

Application.

Seasonal and perennial allergic rhinitis, pollen disease, allergic conjunctivitis, chronic idiopathic urticaria, itching, angioedema; complex therapy of atopic dermatitis, chronic eczema, atopic asthma.

Contraindications.

Hypersensitivity, including the hydroxyzine, pregnancy, lactation, Children up to age 6 Months.

Restrictions apply.

Chronic renal failure (moderate and severe degrees of severity), advanced age (may decrease glomerular filtration rate).

Pregnancy and breast-feeding.

Contraindicated.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

At the time of treatment should stop breastfeeding (It passes into breast milk).

Side effects.

From the nervous system and sensory organs: drowsiness (14%), fatiguability (6%), excitation, headache, dizziness, anxiety, nervousness, emotional lability, impaired concentration and thought, insomnia, depression, euphoria, confusion, amnesia, depersonalization, ataxia, dystaxia, tremor, hyperkinesia, leg cramps, paraesthesia, disfonija, myelitis, paralysis, ptosis, ccomodation and vision, sore eyes, glaucoma, xerophthalmia, conjunctivitis, bleeding in the eye, ototoxicity, noise in ears, deafness, violation of the sense of smell.

From the digestive tract: dry mouth (5%), change or an absence of taste perception, increased appetite, anorexia, stomatitis (including ulcerative), color change and swelling of tongue, increase salivation, increased caries, thirst, vomiting, dyspepsia, gastritis, abdominal pain, flatulence, diarrhea, constipation, hemorrhoids, ground, rectal bleeding, abnormal liver function.

Cardio-vascular system: migraine, extremely rare - palpitation, hypertension, heart failure.

From the respiratory system: rhinitis, nose bleed, nosovoй polyp, pharyngitis, cough, sinusitis, bronchitis, increase in bronchial secretions,bronchospasm, dyspnoea, upper respiratory tract infection, pneumonia, hyperventilation.

With the genitourinary system: urinary retention, swelling, polyuria, dizurija, hematuria, urinary tract infection, cystitis, the weakening of the libido, dysmenorrhoea, intermenstrual bleeding, menorragija, vaginitis.

On the part of the musculoskeletal system: arthralgia, arthritis, arthrosis, myalgia, backache, muscular weakness.

For the skin: xerosis, rash, blisters, itch, acne, furunculosis, dermatitis, eczema, hyperkeratosis, эritema, increased sweating, alopecia, angioedema, hypertryhoz, photosensitivity, seborrhea.

Other: malaise, fever, chills, tides, dehydration, diabetes, lymphadenopathy, breast pain, weight gain, allergic skin reactions, incl.

hives.

Cooperation.

Theophylline slightly (on 16%) Lowering. Compatible with azithromycin, psevdoépinefrinom, ketoconazole, Erythromycin, diazepam and cimetidine.

Overdose.

Symptoms: drowsiness, possible - anxiety, urinary retention, tremor, tachycardia, itch, rash.

Treatment: gastric lavage, appointment of activated carbon; supportive and symptomatic therapy. Hemodialysis nyeeffyektivyen.

Dosing and Administration.

Inside, adults and children over 6 years - 10 mg 1 once a day or 5 mg 2 once a day, children 2-6 years - 5 mg 1 once a day or 2,5 mg 2 times a day, or (depending on the severity of the condition or response), children 1-2 years - 2,5 mg 2 once a day, children 6-12 months - 2,5 mg 1 once a day.

Patients with renal insufficiency dose reduced according to creatinine clearance: creatinine clearance 30-49 ml / min - 5 mg 1 once a day, at 10-29 ml / min - 5 mg a day.

Precautions.

Not recommended simultaneous application of funds, CNS depressants, and drinking. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cooperation

Active substance	Description of interaction
Azelastin	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduces the speed of psychomotor reactions; the combined use of inappropriate and is not recommended.
Azithromycin	Do not change (mutually) effect; permissible combined use.
Alprazolam	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Buprenorphine	FMR: synergism. It enhances the effect on the central nervous system (deprimatsiya deepens and further reduced the speed of psychomotor reactions).
Buspirone	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduces the speed of psychomotor reactions.
Haloperidol	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Gidroksizin	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduces the speed of psychomotor reactions.
Diazepam	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Droperidol	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Zolpidem	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduced rate of psychomotor reactions.
Izofluran	FMR: synergism. Strengthens (in postanesthesia period) deprimiruyuschie effect and decrease the speed of psychomotor reactions.
Quetiapine	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Ketamine	FMR: synergism. Strengthens (in postanesthesia period) deprimiruyuschie effect and decrease the speed of psychomotor reactions.
Ketoconazole	Do not change (mutually) effect; permissible combined use.
Klozapyn	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Codeine	FMR: synergism. It enhances the effect on the central nervous system (deprimatsiya deepens and further reduced the speed of psychomotor reactions).
Lorazepam	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduces the speed of psychomotor reactions.
Midazolam	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduced rate of psychomotor reactions.
Morphine sulfate	FMR: synergism. It enhances the effect on the central nervous system (deprimatsiya deepens and further reduced the speed of psychomotor reactions).
Oxazepam	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduces the speed of psychomotor reactions.
Olanzapine	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Perfenazyn	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Promethazine	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduces the speed of psychomotor reactions; the combined use of inappropriate and is not recommended.
Propofol	FMR: synergism. Strengthens (in postanesthesia period) deprimiruyuschie effect and decrease the speed of psychomotor reactions.
Risperidone	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Theophylline	FKV. In large doses, (400 mg) somewhat reduces clearance.
Tioridazin	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Trifluoperazine	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Phenobarbital	FMR: synergism. Enhances deprimatsiyu and reduced rate of psychomotor reactions.
Fentanyl	FMR: synergism. It enhances the effect on the central nervous system (deprimatsiya deepens and further reduced the speed of psychomotor reactions).
Flufenazin	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Xlordiazepoksid	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduces the speed of psychomotor reactions.
Chlorpromazine	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Chlorprothixene	FMR: synergism. Strengthens (mutually) deprimatsiyu, reduces the speed of psychomotor reactions.
Erythromycin	Do not change (mutually) effect; permissible combined use.
Ethanol	FMR: synergism. Strengthens (mutually) deprimatsiyu and reduced rate of psychomotor reactions; at the time of treatment should abandon spirits.