Levonorgestrel
When ATH:
G03AC03
Pharmacological action.
Contraceptive.
Application.
Contraception, idiopathic menorrhagia, protecting the endometrium from hyperplasia in estrogen replacement therapy (for intrauterine system).
Contraindications.
Hypersensitivity, hormone-dependent tumors, propensity to thromboembolism, otosclerosis, acute disease or liver tumor, infectious diseases of the genitourinary system, pregnancy, lactation (optional waiver of breastfeeding).
Side effects.
Rarely is a mezhmenstrual'nye spotting, menstrual irregularities, mastalgïya, nausea, headache, acne, fluid retention, girsutizm, depression, dermatitis, hair loss.
Dosing and Administration.
Inside, in the evening after meals-on 1 Table. daily for 21 day. Intrauterine system is administered for 4-6 days of the menstrual cycle, After artificial abortion is directly or, rather, after the next menstruation; after normal spontaneous delivery — no earlier, than 6 Sun.
Cautions.
The design of the intrauterine system allocates levonorgestrel with speed 20 mg / day. At long intermenstrual spotting need additional inspection (for further diagnosis).
Cooperation
| Active substance | Description of interaction |
| Akarʙoza | FMR: antagonizm. Against the background of weakened effect of levonorgestrel; the combined appointment requires constant monitoring of blood glucose concentrations. |
| Glipizide | FMR: antagonizm. Against the background of weakened effect of levonorgestrel; the combined appointment requires constant monitoring of blood glucose concentrations. |
| Insulin soluble [pork monocomponent] | FMR: antagonizm. Against the background of weakened effect of levonorgestrel (may require higher doses). |
| Carbamazepine | FKV. FMR: antagonizm. Inducing activity of hepatic CYP450, It reduces plasma level and reduces the reliability of the contraceptive effect; the combined use possible breakthrough bleeding. |
| Levothyroxine sodium | FKV. Against the backdrop of increasing levels of levonorgestrel in plasma thyroxine binding globulin (may require higher doses). |
| Retinol | FKV. On the background of levonorgestrel may significantly increase the plasma level. |
| Rifampicin | FKV. As an inducer of liver enzymes accelerates biotransformation, may weaken the effect and reduce the reliability of contraception. |
| Phenytoin | FKV. Inducing activity of cytochrome P450, accelerates biotransformation, may weaken the contraceptive effect. |
