Ethinylestradiol

When ATH:
G03CA01

Characteristic.

A white or creamy white crystalline powder. Practically insoluble in water, soluble in alcohols and vegetable oils.

Pharmacological action.
Estrogenic, anabolic, gipolipidemicescoe.

Application.

Some forms of endocrine infertility, severe pathological menopause, dysfunctional uterine bleeding, androgen-dependent prostate cancer, some forms of breast cancer.

Contraindications.

Hypersensitivity, tromboflebit, active hepatitis, cirrhosis of the liver, arterial hypertension, breast cancer and endometrial cancer, porphyria, pregnancy.

Side effects.

Violation of calcium metabolism, edematous syndrome, nausea, headache, thromboembolism, arterial hypertension; men - gynecomastia.

Cooperation.

Effectively reduces barbiturates (accelerate oxidation).

Dosing and Administration.

/ M, with amenorrhea and oligomenorrhea - 0.02-0.1 mg / day for 20 days, more / m is administered progesterone during 5 days - 5 mg / day. Dysmenorrhea, treatment is initiated with 4-5 days of the menstrual cycle - at 0.01-0.03 mg / day (for 3 admission) during 20 days, repeat the treatment every 2-3 months. To stop lactation appointed in the first three days after childbirth 0,02 mg 3 once a day, then the next three days - 0,01 mg 3 once a day, then - on 0,01 mg / day once daily for 3 days. In the treatment of acne vulgaris - at 0.03-0.06 mg / day. When prostate cancer administered in an initial dose of 0.05-0.1 mg 3 twice a day with a gradual reduction to maintenance - 0,05 mg / day. When menopause syndrome - for 0,05 mg / day.

Cooperation

Active substanceDescription of interaction
Amoksiцillin + Clavulanic acidFMR. Reduces the reliability of contraception and increases the risk of "breakthrough bleeding".
Ampicillin + OxacillinFMR. Reduces the reliability of contraception and increases the risk of "breakthrough bleeding".
CarbamazepineFKV. FMR. It lowers blood (inducing CYP450, accelerates biotransformation), reduces the reliability of contraception and increases the risk of "breakthrough bleeding".
RifampicinFKV. FMR. It lowers blood (inducing CYP450, accelerates biotransformation) and reduces the reliability of contraception.
TopiramateFKV. FMR. It lowers blood (accelerates biotransformation), reduces the reliability of contraception and increases the risk of "breakthrough bleeding".

Back to top button