Valproic Acid

When ATH:
N03AG01

Characteristic.

White crystalline powder. The easily soluble in water and alcohol.

Pharmacological action.
Antiepileptic, miorelaksiruyuschee, sedation.

Application.

Various forms of generalized seizures: Small (absences), big (convulsive) and polymorphic; used in focal seizures, children tick.

Contraindications.

Hypersensitivity, incl. "Family" (death of close relatives in patients receiving valproic acid), liver and pancreas (some patients may be a significant reduction in metabolism in the liver), gyemorragichyeskii diatyez.

Restrictions apply.

Childhood (co-administration of several anticonvulsants), bone marrow aplasia.

Pregnancy and breast-feeding.

It contraindicated in I trimester of pregnancy. Perhaps in the II and III trimester of pregnancy, if the effect of therapy outweighs the potential risk to the fetus.

Category actions result in FDA - D. (There is evidence of the risk of adverse effects of drugs on the human fetus, obtained in research or practice, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk, if the drug is needed in life-threatening situations or severe disease, when safer agents should not be used or are ineffective.)

At the time of treatment should stop breastfeeding.

Side effects.

Nausea, vomiting, diarrhea, stomach ache, Anorexia or increased appetite, liver dysfunction, drowsiness, tremor, paresthesia, confusion, peripheral edema, bleeding, leukopenia, thrombocytopenia. In the long admission-temporary hair loss.

Cooperation.

The effect of increasing other anticonvulsants, sedatives and opiates. Diarrhoeal disorders rarely develop on the background of antispasmodics and envelop funds. Alcohol and other hepatotoxic agents increases the likelihood of liver damage, anticoagulants or acetylsalicylic acid is the risk of bleeding.

Dosing and Administration.

Inside, during or immediately after a meal. Daily intake for adults at the beginning of treatment is 0.3-0.6 g, within 1-2 weeks it gradually increased to 0.9-1.5 g, under dose for adults is 0.3-0.45 g. Daily dose for children is 15-50 mg/kg (in the beginning — 15 mg / kg, then a gradual increase of 5-10 mg/kg/week).

Cooperation