Mefloxin
When ATH:
P01BA05
Characteristic.
Powder bitter and slightly burning taste.
Pharmacological action.
Protivoprotozoynymi, antimalarial.
Application.
Malaria (treatment of mild to moderate forms, prevention), called hlorohinustoychivymi, pyrimethamine-sulfadoksinustoychivymi or multiple-resistant strains Plasmodium falciparum; malaria prevention, called P. vivax, P. oval, P. malariae, before leaving the regions with a high risk of infection by strains Plasmodium falciparum, resistant to other anti-malarial drugs; emergency treatment for suspected malaria and the impossibility of applying for emergency medical care.
Contraindications.
Hypersensitivity, and other epileptic seizures, acute psychosis.
Restrictions apply.
Pregnancy, mental illness, severe liver, Age to 2 age or body weight to 15 kg.
Side effects.
When using prophylactic doses: transient gastrointestinal disturbances (nausea, vomiting, epigastric pain, diarrhea), headache, dizziness, fainting, arrythmia, unstable changes in laboratory parameters (leukocytosis, thrombocytopenia, transaminase elevation), reversible neuropsychiatric disorders (convulsions, depression, psychoses). When using therapeutic doses: expressed dyspepsia, fatigue, neuropsychiatric disorders (dizziness, headache, visual disturbances, noise in ears, insomnia, anxiety, anxiety, excitation, depression, disorientation, memory decline, confusion, hallucinations, acute psychosis, or seizures), reduction or increase in blood pressure, tachycardia or bradycardia, transient arrhythmias and conduction of the heart, rashes, alopecia, itching, hives, erythema multiforme, changes in laboratory parameters.
Cooperation.
Amplifies braking conductivity and excitability of heart muscle, caused by beta-blockers, xininom, xinidinom, galofantrinom, calcium channel blockers. Reduces the antiepileptic valproic acid activity, divalproex sodium, the immunogenicity of live typhoid vaccines. Chloroquine, Quinine increases the risk of seizures.
Overdose.
Symptoms: nausea, vomiting, vertigo, stomach ache, disorders of the central and peripheral nervous systems, Cardiovascular.
Treatment: induction of vomiting and gastric lavage, simptomaticheskaya therapy. It requires continuous monitoring of hemodynamic parameters, ECG, neuropsychological status.
Dosing and Administration.
Inside, after meal, drinking plenty of water, milk or other. liquids; permissible pre-grinding tablets. The total dose is 15-25 mg/kg (for an average adult is 1-1, 5 g), one or 2-3 reception at intervals of 6-8 h. If you have symptoms of malaria it is recommended for adults to take at one time 3 Table., then after 6-8 h (the absence of side effects) -still 2 Table., and after 6-8 hours is still 1 Table. For the prevention of malaria for 2-3 weeks prior to the expected arrival of a dangerous infection with malaria area appointed 5 mg / kg 1 once a week; in some cases, let's say for the reception 1 Weeks usual prophylactic dose, or upon arrival at high doses (adult 250 mg daily for 3 days, then 1 once a week). After leaving the dangerous area prophylactic continued for another 4 Sun.
Precautions.
Patients should consult a doctor even if, If the self-treatment felt full recovery. In the I trimester of pregnancy can appoint, if the benefits of the expected rate outweighs the potential risk to the fetus. Women of childbearing age during treatment need reliable methods of contraception. Not recommended for severe malaria (the effect is slow and it is impossible, parenteral administration). If vomiting occurs within 30 minutes after taking the full dose reappoints, If vomiting occurs later (30-60 min) — dose reduced by half. Neuropsychiatric disorders (alarm, depression, disturbances of consciousness) require the abolition. We recommend using mefloquine for malaria, caused P. vivax, only in combination with other drugs (relapse prevention held an 8-aminoquinoline). When quinine or quinidine taking mefloquine can be no earlier, than 12 no. When administered for a long time (not a desirable reception 1 year) A periodic analysis of liver function tests and eye examination. During treatment should abandon activities, requiring attention and fine motor coordination.
