Lamotrigine

When ATH:
N03AX09

Characteristic.

Powder from white to pale cream color, slightly soluble in water.

Pharmacological action.
Anticonvulsant.

Application.

Seizures: convulsive (tonico-clauniceskie), partial and generalized, Lennox-Gastaut syndrome (resistant to other antikonvulsantnym tools).

Contraindications.

Hypersensitivity, expressed human liver, hepatic failure, pregnancy, breast-feeding, childhood (to 12 years).

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

Headache, dizziness, drowsiness, sleep disorders, feeling tired, aggressiveness, confusion, nausea, liver dysfunction, lymphadenopathy, leukopenia, thrombocytopenia, skin rash, angioedema, Syndrome Stevens - Johnson, toxic skin necrosis.

Cooperation.

Other anti-convulsants (Carbamazepine, phenytoin), inducing system zitohroma P450, paracetamol eliminatiu up.

Overdose.

Symptoms: ataxia, nistagmo, dizziness, drowsiness, headache, vomiting, coma.

Treatment: gastric lavage, Activated carbon.

Dosing and Administration.

Inside, from 25-200 mg/day (to 700 mg per day); dose, frequency and duration of the admission picked individually.

Precautions.

It will be appreciated, that sudden elimination lamotrigina could trigger increases stroke, and the dose should be reduced gradually.

Cooperation