Imipramine

When ATH:
N06AA02

Characteristic.

The white crystalline powder. The easily soluble in water and alcohol.

Pharmacological action.
Antidepressant, timolepticheskoe, psihostimulirutee, antidizuricescoe.

Application.

Depressive states of various etiologies: astenodepressivnyh syndrome, depression (endogenous, involutional, climacteric, reaktivnaя, Alcoholic), depression when psychopathy and neurosis, functional enuresis in children.

Contraindications.

Hypersensitivity, renal failure, CHD, tachycardia, congestive heart failure, early post-infarction period, tendency to seizures, schizophrenia, epilepsy, glaucoma, prostate adenoma, atonic bladder, pregnancy, childhood (to 2 years).

Side effects.

Headache, dizziness, chrezmernaya sedation, paraesthesia, tremor, convulsions, dysarthria, incoordination, sleep disturbance, excitation, hallucinations, dry mouth, constipation, hepatitis, tachycardia, arrhythmia, orthostatic hypotension, urinary retention, ccomodation, leukocytosis or leukopenia, agranulocytosis, gynecomastia, galactorrhea, decreased libido, impotence, weight gain, photosensitivity, hair loss, fever, hyperhidrosis.

Cooperation.

Incompatible with alcohol, MAO inhibitors (strengthening the psychostimulant effects). Reduces the effectiveness of phenytoin. Anticholinergics, phenothiazines and benzodiazepines increase the sedative and central holinoliticheskoy activity imipramine.

Overdose.

Symptoms: dizziness, excitation, ataxia, convulsions, stupor, coma, midriaz, tachycardia, arrhythmia, OF блокада, collapse at high venous pressure, hypotension, respiratory depression, cyanosis, vomiting, fever.

Treatment: gastric lavage with saline, inside-activated carbon, in / in the slow introduction of physostigmine salicylate, symptomatic treatment (anticonvulsants).

Dosing and Administration.

Inside, within 10-14 days dose gradually increased to 150-250 mg/day and after clinical effect gradually reduced to a supporting-50-150 mg. In shallow depressions — 75-150 mg/day, supporting is 25-50 mg/day. Children 3-6 years 1 h to sleep — 5 mg; 7-12 years - 25 mg.

/ M - By 25 mg 3 times a day in combination with oral intake 25 mg, daily dose can be increased to 25 mg. Through 7 Days begin reducing the dose to maintenance (by 25 mg / day) and inside designated 50 mg. With 13 days only oral appointment — 350 mg / day 3 admission.

Precautions.

In the initial period of therapy necessarily constant medical monitoring of patients with suicidal tendencies. During treatment, it prohibits the use of alcoholic beverages. It is recommended to control the cells of peripheral blood and liver function. Appoint follows through 2 Sun (no sooner) after discontinuation of MAO inhibitors, start with small doses — 25 mg / day. When using diabetic patients require dose adjustment of oral antidiabetic drugs. It will be appreciated, injection that contains sulfites, that can cause or exacerbate type reaction anaphylaxis. In the initial period of therapy is necessary to give up driving and the performance of potentially hazardous work.

Cooperation