Piroxicam (When ATH M01AC01)

When ATH:
M01AC01

Characteristic.

White or white with a slightly yellowish white crystalline powder. Soluble in chloroform (1:100), in warmed ethanol and methanol (1:1000), difficult to dissolve in water.

Pharmacological action.
Anti-inflammatory, analgesic, pyretic, antiagregatine.

Application.

Inflammatory and degenerative diseases of joints and spine, accompanied by pain syndrome, incl. rheumatoid arthritis, rheumatism, ankylosing spondylitis (ankylosing spondylitis), osteoarthritis, juvenile chronic arthritis, Tendinitis, tendinitis, plechekistevoy syndrome, frozen shoulder, acute attack of gout; pain of various origins: neuralgia, myalgia, primary dysmenorrhea, pain postoperative and posttraumatic, incl. sports injuries (injury, dislocation, tension), pain and swelling in joints, tendons and muscles, due to overexertion and others.; acute infectious and inflammatory diseases of the upper respiratory tract.

Contraindications.

Hypersensitivity, incl. to other NSAIDs, erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), «Aspirinovaya» asthma, expressed human liver and / or kidney, gyemorragichyeskii diatyez, changes in the blood picture of unknown origin (incl. history), inflammatory changes or bleeding in the rectum and anus, incl. proctitis (when using suppositories); pregnancy, lactation, Children and Youth age (injection - up 18 years; gel, ointment, suppozytoryy - to 14 years).

Restrictions apply.

Erosive and ulcerative lesions of the gastrointestinal tract in history, bronchial asthma, allergic diseases, heart failure and other diseases, accompanied by edema, arterial hypertension.

Pregnancy and breast-feeding.

Contraindicated in pregnancy.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: dizziness, headache, irritability, drowsiness or insomnia, weakness, depression, hallucinations, noise in ears, blurred vision, eye irritation.

Cardio-vascular system and blood (hematopoiesis, hemostasis): increase or decrease in blood pressure, heartbeat, anemia, thrombocytopenia, leukopenia, eozinofilija, reduction of hemoglobin and hematocrit, gemorragii.

From the digestive tract: dry mouth, stomatitis, irritation of the gastrointestinal tract, nausea, belching, anorexia, diarrhea or constipation, flatulence, krovotochivosty right, epigastric pain, erosive and ulcerative lesions of the gastrointestinal tract and the occurrence of bleeding, abnormal liver function (increase in liver transaminases).

With the genitourinary system: renal failure, acute interstitial nephritis.

Other: allergic reactions (itch, erythema; swelling, incl. person, hands; Stevens-Johnson syndrome, Lyell's syndrome, very rarely - anaphylactic reactions, bronchospasm, photosensitivity, rash), swelling (mainly the lower extremities in patients with impaired cardiac function), Sweating, increase of urea, hyperkalemia, Hypo- or hyperglycemia, increase or decrease in body weight.

Local reactions: irritation of the mucous membrane of the rectum, tenesmus, pain and unpleasant feeling of heaviness in the anal area (suppozitorii); when applied to the skin - irritation, incl. itch, redness, rash, burning (prolonged use).

Cooperation.

Displace from its association with blood proteins other drugs. Decreases effectiveness of antihypertensive drugs. Compared to other NSAIDs and corticosteroids increases the risk ultserogennogo. It increases the risk of hyperkalemia in combination with potassium-sparing diuretics and other potassium-containing drugs. Increasing the concentration of phenytoin and lithium in the blood. Anticoagulants increase bleeding risk. Acetylsalicylic acid reduces the concentration of piroxicam in the blood to 80% source.

Overdose.

Symptoms: drowsiness, blurred vision, at very high doses - unconsciousness, coma.

Treatment: gastric lavage, administration of activated charcoal, Antacids (to reduce the suction), simptomaticheskaya therapy.

Dosing and Administration.

Inside, during or immediately after a meal. Inflammatory and degenerative-dystrophic diseases of joints: 20 mg 1 once a day (from 10 mg 1 once a day before 30 mg / day in 1-2 reception). Rheumatoid arthritis and rheumatism active phase: 40 mg / day in divided doses for 1-2 2 days, maintenance dose - 20 mg / day. Acute gout attack: 40 mg 1 once a day for 2 days, then 20 mg 2 times a day for 4-6 days. Post-operative and post-traumatic pain: 20 mg 1 once a day (if necessary - 40 mg / day in 1-2 reception).

The maximum daily dose for adults - 40 mg.

/ M: 1 once a day, when expressed pain syndrome - 40 mg, with moderate pain syndrome - 20 mg, The maximum daily dose - 40 mg. The injection is carried out in 1-2 days, After arresting the acute stage of the transition process, possibly, maintenance therapy with other medicinal forms (tablets, capsules, etc.).

Rectal: 10-40 mg 1-2 times a day, the maximum daily dose for adults - 40 mg.

Outwardly: gel or ointment applied to the skin in the painful area and rubbed 3-4 times per day, duration of therapy depends on the severity of the disease and the nature of the damage.

Precautions.

Before applying, incl. local, patients with bronchial asthma, allergic rhinitis, with polyps of the nasal mucosa, chronic obstructive airways disease should consult a doctor. In the period of treatment is necessary to control the cellular composition of the blood, renal and hepatic function.

During the period of treatment can not drink alcoholic beverages.

Avoid contact with the gel or ointment on the mucous membranes, in the eyes, open wounds, etc..

Cooperation