Clomipramine

When ATH:
N06AA04

Pharmacological action.
Antidepressant, timolepticheskoe, sedation, psihostimulirutee.

Application.

Depressive syndrome (endogenous, jet, neurotic, organic, larvirovanny, involutional), psihopatiâ, schizophrenia, chronic pain and physical illness, dysthymic states within psychotic disorder in children and adolescents, obsessive-compulsive disorder and phobias, catalepsy in narcolepsy, bed-wetting.

Contraindications.

Hypersensitivity (incl. other antidepressants from the group dibenzazepine), recent myocardial infarction, treatment MAO inhibitors, pregnancy, lactation.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

Dry mouth, profuse sweating, tremor, dizziness, Parez akkomodacii, urinary retention, orthostatic hypotension, lethargy, allergic skin reactions. Rarely - liver dysfunction, hyperpyrexia, convulsions, agranulocytosis.

Cooperation.

Incompatible with MAO inhibitors.

Overdose.

Symptoms: conduction abnormalities and arrhythmias, insomnia, confusion, strengthening or developing a phobia.

Treatment: gastric lavage; with severe anticholinergic symptoms - physostigmine 0.5–2 mg IV or IM.

Dosing and Administration.

Inside, with depression and phobias prescribed by 25 mg 2-3 times a day; during the first week, the dose is gradually increased to 50 mg 2-3 times a day, and then (after the clinical effect) switch to support 25 mg 2-3 times a day.

/ M administered at 25-50 mg / day, dose is gradually increased by 25 mg daily up to 100–150 mg/day. B / drip administered at 50-75 mg (dissolved in isotonic glucose solution or sodium chloride) within 1.5–3 hours 1 once a day. For chronic pain, the dose is 10-150 mg / day; in the elderly, the initial daily dose is 10 mg with a gradual increase to 30-50 mg / day during 10 days. For children, the initial daily dose is 10 mg with a gradual increase over 10 days before 20 mg / day (aged 5-7 years), up to 20–50 mg/day (aged 8-14 years), to 50 mg / day (the age 14 years).

Precautions.

During treatment should avoid alcohol.