Ofloxacin (When ATH S01AX11)

When ATH:
S01AX11

Characteristic.

Fluoroquinolone antibacterial agent II generation. Crystalline powder slightly yellowish, without smell, bitter taste. It is soluble in water and alcohol.

Pharmacological action.
Antibacterial, bactericide.

Application.

Severe infections of the respiratory tract (pneumonia, lung abscess, bronchiectasis, exacerbation of bronchitis), ENT (except acute tonsillitis), skin and soft tissue, bone and joints, abdomen, pelvic, kidney, urinary tract, genital (incl. gonorrhea, prostatitis), chlamydial infections, septicemia, bacterial corneal ulcers, conjunctivitis; complex therapy of tuberculosis, prevention of infection in immunocompromised patients.

Contraindications.

Hypersensitivity (incl. to other fluoroquinolones, xinolonam), epilepsy, dysfunction of the central nervous system with lowering the threshold of convulsive readiness (after traumatic brain injury, stroke, inflammatory CNS), pregnancy, lactation, Children and Youth age (to 18 years).

Side effects.

Dyspepsia, nausea, vomiting, diarrhea, anorexia, abdominal pain, dry mouth, psevdomembranoznыy colitis; dizziness, headache, insomnia, anxiety, reduction reaction rates, excitation, intracranial hypertension, tremor, convulsions, nightmares, hallucinations, psychosis, paraesthesia, Phobias, dystaxia, taste, olfactory, of view, diplopia, disorders of color perception, loss of consciousness, transient increase in bilirubin and liver enzymes in the blood plasma, cardiovascular collapse, acute interstitial nephritis, violation of renal excretory function with increased levels of urea and creatinine, gipoglikemiâ (in patients with diabetes mellitus), hepatitis, jaundice, vasculitis, Tendinitis, myalgia, arthralgia, vaginitis, hemolytic and aplastic anemia, thrombocytopenia, including thrombocytopenic purpura, leukopenia, neutropenia, agranulocytosis, pancytopenia, dysbiosis, superimposed infection, photosensitivity, allergic reactions (skin rash, itch, angioedema, incl. laryngeal, pharyngeal, person, the vocal cords, bronchospasm, hives, erythema multiforme exudative, Syndrome Stevens - Johnson, toxic skin necrosis, anaphylactic shock).

When used in ophthalmology: burning sensation and discomfort in the eyes, redness, itching and dryness of the conjunctiva, photophobia, lacrimation.

Cooperation.

Antacids (calcium and magnesium), iron sulfate, saline laxatives, sucralfate, reduce the absorption of zinc and reduce the activity (interval between doses should be at least 2 no), probenecid, cimetidine, furosemide and methotrexate inhibit the excretion and may increase toxicity. Increases concentration of glibenclamide. Should not be mixed in solution with heparin (risk of precipitation).

Overdose.

Symptoms: drowsiness, nausea, vomiting, dizziness, disorientation, lethargy, confusion.

Treatment: gastric lavage, maintaining vital functions.

Dosing and Administration.

Inside, with a small amount of water; adults — 200-400 mg on 2 times a day or 400-800 mg 1 once a day (no more) 7-10 days; in gonoree- 400 mg dose. B / (drop, during 1 no), in severe infections - 200 mg 5% glucose solution. Against the backdrop of liver disease daily dose should not exceed 400 mg, kidneys — depends on creatinine clearance: When Cl creatinine 20-50 mL/min first dose is 200 mg, then 100 mg every 24 no, less 20 ml / min - 200 mg, further 100 mg every 48 no.

In ophthalmology - By 2 drops 0,3% solution in the eye every 2-4 hours for 2 days, then - 4 once a day (to 5 days).

Precautions.

After the disappearance of clinical signs of treatment continues 2-3 days. Be wary appoint patients with atherosclerosis of cerebral vessels. There should be continuous monitoring in the combined use with insulin, caffeine, theophylline, cimetidine, cyclosporine, NSAIDs, oral anticoagulants and drugs, metabolized by the cytochrome P450.

Children applies only when life is threatened (because of the risk of side effects). Do not inject subkonyunktivalno or introduce into the anterior chamber. With the rapid on / in a possible decrease in blood pressure. The treatment period should not be subjected to sunlight or UV irradiation, to abstain from activities, requiring quickness of psychomotor reactions (Driving license, work with potentially dangerous machinery) and alcohol intake.

Cooperation