Aminofillin

When ATH:
R03DA05

Characteristic.

It is a mixture, consisting of 80% teofillina (1,3-dimetilksantin) and 20% ethylenediamine (1,2-ethylenediamine). White or white with a yellow tinge crystalline powder with a faint smell of ammonia. Soluble in water, aqueous solutions have a pH 9,0-9,7.

Pharmacological action.
Bronchodilator, tokoliticheskoe, diuretic, antispasmodic.

Application.

Chronic obstructive bronchitis, bronchial asthma (the drug of choice in patients with asthma and physical stress as an additional tool in other forms), asthmatic status (complementary therapies), emphysema, neonatal apnea (state, characterized by periods of no breathing during 15 and accompanied with cyanosis and bradycardia), Cheyne - Stokes.

Contraindications.

Hypersensitivity, arrhythmia, arterial hypertension, myocardium pathology, myocardial infarction, heart failure, acute and chronic (acute phase) gastritis, gastric ulcer and duodenal ulcer, prostate adenoma, diarrhea, cystic disease of breast, alcoholism, pulmonary heart, fever, anoxemia, respiratory tract infections, abnormal liver function, hyperthyroidism, chronic and acute renal failure, edematous syndrome, gipernatriemiya, diseases of the rectum, breast-feeding.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

Gastro-reflux эzofahealnыy (heartburn, vomiting), chest pain, heartbeat, gipotenziya, dizziness, tachypnea, feeling flares, headache, allergic reactions (Sweating, fever), injection site reactions (packing, hyperemia, soreness).

Cooperation.

It increases the likelihood of side effects of glucocorticoids, mineralokortikoidov (gipernatriemiya), for narcosis (increased risk of ventricular arrhythmias), xanthine and funds, CNS stimulants (increases neurotoxicity), beta-agonists. Reduces the specific activity of lithium salts. Oral contraceptives (estrogensoderzhaschie), antidiarrheal drugs, impaired intestinal sorbents, а H₂-histamine blockers, ftorkhinolony, BCC, beta-blockers, mexiletine, enhance the effect of erythromycin (It binds to the enzyme cytochrome P450 biotransformation and slow aminophylline).

Overdose.

Symptoms: anorexia, diarrhea, nausea, vomiting, epigastric pain, gastrointestinal bleeding, tachypnea, flushing of the face, tachycardia, ventricular arrhythmias, insomnia, anxiety, photophobia, generalized seizures.

Treatment: removal of the drug, stimulation of its removal from the body (gastric lavage, diurez, hemosorption, plasmasorption, hemodialysis, pyeritonyealinyi dialysis), simptomaticheskaya therapy.

Dosing and Administration.

B /, / m, inside. Obstructive lung disease. In the acute phase of an adult: начальная доза составляет 5–6 мг/кг (при дальнейшем увеличении дозировки препарата на каждые 0,5 мг/кг происходит возрастание концентрации аминофиллина в крови на 1 ug / ml); must be considered, что концентрация аминофиллина в сыворотке крови не должна превышать 20 ug / ml (may develop side effects); поддерживающая доза — для курильщиков 4 mg / kg every 6 no; для некурящих и больных с патологией печени — 2 mg / kg every 8 no; детям начальная доза — 5–6 мг/кг, supports (in mg / kg) — рассчитывается по формуле: Children under 6 Months - 0,07 x age in weeks + 1,7 every 8 no, Children 6 Months before 1 year - 0,05 x age in weeks + 1,25 every 6 no, from 1 Year to 9 years - 5 mg / kg every 6 no, from 9 to 12 years - 4 mg / kg every 6 no, from 12 to 16 years - 3 mg / kg every 6 no.

Вне обострения взрослым начальная доза — 6–8 мг/кг/сут (maximum 400 mg / day), razdelennaya 3-4 accepts; with good endurance may further increase the dose to 25% через каждые 2–3 дня — до максимальной 13 mg / kg / day (900 mg / kg / day); children: the initial dose - 16 mg / kg / day (maximum 400 mg / day), razdelennaya 3-4 accepts; with good endurance may increase the dose to 25% через каждые 2–3 дня — до максимальной суточной, which makes up for the age 1 year - 0,3 x age in weeks + 8,0, from 1 Year to 9 years - 22 mg / kg, from 9 to 12 years - 20 mg / kg, from 12 to 16 years - 18 mg / kg, senior 16 years - 13 mg / kg.

При апноэ новорожденных начальная доза составляет 5 mg / kg (administered by nasogastric tube), maintenance dose - 2 mg / kg, in 2 admission. The course of treatment amounts to a few weeks, в редких случаях — месяцев.

Cooperation