Ethacrynic acid

When ATH:
C03CC01

Pharmacological action.

Diuretic.

Application.

Edematous syndrome of various genesis (congestive heart failure, Portal cirrhosis, nephrotic syndrome), arterial hypertension (in a combination therapy), pulmonary edema, cephaledema.

Contraindications.

Hypersensitivity, anurija, expressed disturbances of water and electrolyte and acid-base balance, pechenochnaya coma, severe diabetes and gout, pregnancy, lactation, natural infancy (to 2 years).

Pregnancy and breast-feeding.

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects.

Anorexia, nausea, vomiting, abdominal pain, diarrhea, acute pancreatitis; orthostatic hypotension, tachycardia, arrhythmia, ototoxic violation, dizziness, headache, muscular weakness, degidratatsiya, metabolic acidosis, kaliopenia, chloropenia, giponatriemiya, gipomagniemiya, hypocalcemia.

Cooperation.

Potassium-sparing diuretics enhance the effect and reduce the hypokalemia and alkalosis. Deepens hypotension, caused by beta-blockers, gidralazinom, verapamil, nifedipine, captopril, clonidine, methyldopa, guanethidine, prazosin, reserpine, ganglioblokatorami (possible orthostatic collapse). Combined with indirect anticoagulants and glucocorticoids increases the more important and hypokalemia salurez. Increases GRT- and nephrotoxicity of other drugs, and the degree of dehydration on the background of laxatives.

Overdose.

Symptoms: expressed disturbances of water-electrolyte metabolism (kaliopenia, chloropenia, gipovolemiя), metabolic alkalosis, hypotension, Arrhythmia.

Treatment: gastric lavage, administration of drugs, correcting the acid-base balance (potassium supplements); if necessary, resuscitation measures to restore the function of breathing and the cardiovascular system.

Dosing and Administration.

Inside, morning, after meal, beginning with 0,05 g / day, if necessary, resuscitation measures to restore the function of breathing and the cardiovascular system.

Precautions.

In cirrhosis application requires careful medical supervision. Treatment should be carried out against the background of diet, rich in potassium, and, if necessary, to prescribe his drugs.

Cooperation