Cefaclor

When ATH:
J01DC04

Pharmacological action.
Broad-spectrum antibacterial, bactericide.

Application.

Infectious diseases, caused by susceptible pathogens - infections of the upper and lower respiratory tract, urinary tract, skin, soft tissue, bone and joints, gonorrhea, acute otitis media, endometritis, intra-abdominal and pelvic infection, postoperative complications microbial (prevention), sepsis (in combination with other antibacterials).

Contraindications.

Hypersensitivity (incl. other beta-lactam antibiotics), severe renal insufficiency, leukopenia, hemorrhagic syndrome.

Pregnancy and breast-feeding.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

Side effects.

Dyspeptic syndrome (nausea, vomiting, diarrhea), dizziness, headache, toxic hepatitis, cholestatic jaundice, acute renal failure, tubulointerstitial nephritis, increase in liver enzymes in the blood serum, kandidomikoz, psevdomembranoznыy colitis, allergic reactions (itching, rash, eozinofilija, seldom-swelling kwinke); With prolonged use, hematological changes - leukopenia, neutropenia, thrombocytopenia, gemoliticheskaya anemia, gipoprotrombinemii (rarely).

Cooperation.

Effect increase aminoglycosides, metronidazol, Polymyxin, rifampicin, Weaken - levomicetin, tetracikliny. Enhances nephrotoxicity butadiona, aminoglycosides, polymyxins. Cholestyramine reduces the absorption of.

Dosing and Administration.

Inside. The batch is individually, depending on the severity and localization of the infection, susceptibility. Adults - the average daily dose 750 mg 3 admission, The maximum daily dose - 4 g, Children - the average daily dose 20 mg / kg 3 admission, The maximum daily dose - 40 mg / kg. Duration of treatment - 7-10 days.

Precautions.

It should be used with caution in renal impairment, malabsorption syndrome.