Cefaclor

When ATH:
J01DC04

Pharmacological action.
Broad-spectrum antibacterial, bactericide.

Application.

Infectious diseases, caused by susceptible pathogens - infections of the upper and lower respiratory tract, urinary tract, skin, soft tissue, bone and joints, gonorrhea, acute otitis media, endometritis, intra-abdominal and pelvic infection, postoperative complications microbial (prevention), sepsis (in combination with other antibacterials).

Contraindications.

Hypersensitivity (incl. other beta-lactam antibiotics), severe renal insufficiency, leukopenia, hemorrhagic syndrome.

Pregnancy and breast-feeding.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

Side effects.

Dyspeptic syndrome (nausea, vomiting, diarrhea), dizziness, headache, toxic hepatitis, cholestatic jaundice, acute renal failure, tubulointerstitial nephritis, increase in liver enzymes in the blood serum, kandidomikoz, psevdomembranoznыy colitis, allergic reactions (itching, rash, eozinofilija, seldom-swelling kwinke); при длительном применении гематологические изменения — лейкопения, neutropenia, thrombocytopenia, gemoliticheskaya anemia, gipoprotrombinemii (rarely).

Cooperation.

Effect increase aminoglycosides, metronidazol, Polymyxin, rifampicin, ослабляют — левомицетин, tetracikliny. Enhances nephrotoxicity butadiona, aminoglycosides, polymyxins. Cholestyramine reduces the absorption of.

Dosing and Administration.

Inside. The batch is individually, depending on the severity and localization of the infection, susceptibility. Взрослым — средняя суточная доза 750 mg 3 admission, The maximum daily dose - 4 g, детям — средняя суточная доза 20 mg / kg 3 admission, The maximum daily dose - 40 mg / kg. Продолжительность лечения — 7–10 дней.

Precautions.

It should be used with caution in renal impairment, malabsorption syndrome.