Cefoperazone

When ATH:
J01DD12

Characteristic.

Cephalosporin antibiotic III generation for parenteral use. Cefoperazone sodium - a white crystalline powder. Easily soluble in water. Molecular weight 667,66.

Pharmacological action.
Broad-spectrum antibacterial, bactericide.

Application.

Bacterial infections of the upper and lower respiratory tract; pneumonia, including nosocomial; urinary tract infection (incl. gonococcal urethritis) and genitals (endometritis), skin and soft tissue, bone and joints, intra-abdominal infections (peritonitis, cholecystitis, kholangit), septicemia, sepsis, meningitis, gonorrhea; prevention of infectious postoperative complications after abdominal, gynecology and orthopedic surgery, and in cardiovascular surgery. Infection, caused Pseudomonas aeruginosa.

Contraindications.

Hypersensitivity, incl. to other cephalosporins; kidney and / or liver failure.

Restrictions apply.

Polyvalent allergy (incl. penicillin, carbapenems), bleeding (history), colitis (history), abnormal liver function, renal dysfunction, pregnancy, lactation, newborn and premature babies.

Pregnancy and breast-feeding.

According to the testimony, with the necessary precautions.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

Side effects.

Allergic reactions: hives, maculopapular rash, eozinofilija, fever, erythema multiforme exudative, Stevens-Johnson syndrome.

Cardio-vascular system and blood (hematopoiesis, hemostasis): Reversible neutropenia, hypocoagulation (by gipoprotrombinemii), increase in PV, anemia, decrease in hemoglobin and hematocrit, unusual bleeding or hemorrhage.

From the digestive tract: nausea, vomiting, diarrhea, psevdomembranoznыy colitis.

Other: vitamin K deficiency, probably due to inhibition of the intestinal flora (cm. Precautions), impairment of renal function, increase in liver transaminases and alkaline phosphatase, giperkreatininemiя; local reactions - soreness at the injection site (when i / m administration), phlebitis (at / in the introduction).

Cooperation.

It can be used in combination therapies with other antibiotics. Increases antimicrobial effect and nephrotoxicity of aminoglycosides; Pharmaceutical incompatible with aminoglycosides (if necessary, the simultaneous use of a prescribed sequence of fractional / v administration using two separate I / Catheter, the first administered ceftazidime). Do not interact with probenecid. Anti effect. In an application with drugs, reduces platelet aggregation (NSAIDs, salicilaty), the risk of bleeding. PM, reduce tubular secretion, cefoperazone slows down and increases its level in the blood. In the interaction with alcohol can teturamopodobnaya reaction.

Dosing and Administration.

/ M, I / (bolus or slow infusion).

/ M, the average daily dose for adults - 2-4 g, with heavy infections is to 8 g ; for children - 50-200 mg / kg, entered every 12 no. With uncomplicated gonococcal urethritis - intramuscularly once at a dose 0,5 g.

In / in slowly, in the form of a solution with a concentration 100 mg / ml, maximum single dose for adults - 2 g, for children - 50 mg / kg; the maximum daily dose for adults - 12 g. For the prevention of infectious postoperative complications - in / in 1-2 g up to 30-60 minutes before the start of the operation and then every 12 no (in most cases, no more than 24 no, in coloproctology and cardiovascular surgery — up to 72 h after surgery).

In severe blockage of the bile ducts, severe liver disease and concomitant renal dysfunction (Cl creatinine <18 ml / min) the dose should be reduced.

Precautions.

During treatment excludes alcohol intake.

With a deficit of vitamin K (most likely in patients with malnutrition, malabsorption, such as cystic fibrosis, alcoholism, as well as long-term parenteral nutrition) It requires the definition of the PX and, if necessary, the appointment of vitamin K. Possible occurrence of false positive reaction for glucose in urine and a positive reaction in the test Coombs.

Use caution with a history of allergic reactions, osobenno to penicillin.

After the disappearance of the clinical signs of the disease should be appointed for a further 2-3 days. In the case of infections, caused Streptococcus pyogenes, treatment lasts at least 10 days.

Prolonged use may grow resistant organisms.