Prazosin

When ATH:
C02CA01

Characteristic.

White or white with Valium a white crystalline powder. Very poorly soluble in 95% alcohol, practically insoluble in water.

Pharmacological action.
Vasodilating, gipotenzivnoe, antidizuricescoe.

Application.

Arterial hypertension, the initial stages of heart failure, benign prostatic hyperplasia.

Contraindications.

Hypersensitivity (incl. other quinazoline), heart failure against constrictive pericarditis, cardiac tamponade, vices with reduced left ventricular filling pressure, pregnancy, lactation.

Restrictions apply.

Giponatriemiya.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

The phenomenon of the first dose (orthostatic hypotension in a sharp position, fainting, headache, weakness, heartbeat), sleep disorders, weakness, fatiguability, depression, nervousness, nausea, dry mouth, diarrhea, frequent urination, edema of the lower extremities, rash.

Cooperation.

It enhances the hypotensive effect of beta-blockers and diuretics.

Dosing and Administration.

Inside. Начальная доза — 0,5–1 мг перед сном в горизонтальном положении, then - 1 mg 2-3 times a day. С интервалом в 5–7 дней суточную дозу можно увеличивать до 6–15 мг (2-3 hours), The maximum daily dose - 20 mg, a maximum effect occurs within 4-6 weeks.

Cautions.

You should regularly monitor the blood pressure and heart rate while standing and lying. Chance of hypotension is higher in patients, receiving diuretics, simpatolitiki, beta-blockers.