Flurbyprofen

When ATH:
M01AE09

Characteristic.

NSAIDs. Phenylpropionic acid derivative.

Pharmacological action.
Anti-inflammatory, analgesic.

Application.

For the relief of pain in the throat in infectious and inflammatory diseases of the oral cavity and pharynx (as a symptomatic agent).

Contraindications.

Hypersensitivity, aggravation of erosive and ulcerative lesions of the gastrointestinal tract (gastric ulcer and duodenal ulcer, yazvennыy colitis), asthma and rhinitis in patients receiving aspirin or other NSAIDs, deficiency of glucose-6-fosfatdegidrogenazы, Children up to age 12 years.

Restrictions apply.

Giperʙiliruʙinemija (incl. Gilbert's syndrome, Dubin-Johnson and Rotor), chronic circulatory insufficiency, swelling, arterial hypertension, hemophilia, hypocoagulation, gastric ulcer and duodenal ulcer (in remission, history), liver and / or kidney failure, inhibition of bone marrow hematopoiesis, hearing loss, pathology of the vestibular apparatus, advanced age.

Pregnancy and breast-feeding.

Application is possible only after consultation with a doctor.

Side effects.

Local reactions when applying lozenges: distorted perceptions of taste and paresthesia (burning, tingling or prickling), ulceration of the mucous membranes of the mouth.

Unwanted side effects, characteristic of drugs of NSAIDs, can be observed when taking flurbiprofena inside the dose of 50-100 mg 2-3 times a day (12-30 Table. in a day).

From the nervous system and sensory organs: headache, dizziness, drowsiness / insomnia, asthenia, depression, tremor, excitation; rare ataxia, paraesthesia, disturbance of consciousness.

Cardio-vascular system and blood (hematopoiesis, hemostasis): increased blood pressure, tachycardia, heart failure; rare anemia (iron, hemolytic, aplastic), agranulocytosis, leukopenia, thrombocytopenia.

From the digestive tract: dyspepsia (nausea, vomiting, heartburn, diarrhea), NSAID-gastropathy, abdominal pain, abnormal liver function; with long-term use in high doses is pitting mucous membrane syndrome, bleeding (gastrointestinal, gingival, hemorrhoidal).

With the genitourinary system: tubulointerstitial nephritis, impairment of renal function, edematous syndrome.

Allergic reactions: skin rash, itch, hives, bronchospasm, photosensitivity, angioedema, anaphylactic shock.

Cooperation.

Inductors of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of reactive hydroxylated metabolites. Flurbiprofen reduces effectiveness urikozuricheskih, antihypertensive drugs and diuretics, enhances the effect of anticoagulants (It increases the risk of bleeding), antiagregantov, fibrinolitikov, hypoglycemic effect of sulfonylureas, side effects of mineralogy- and glucocorticoids, estrogen. It increases blood concentration of lithium preparations, methotrexate.

Overdose.

Symptoms: drowsiness, excitation, nausea, headache, dizziness, epigastric pain, diplopia, mioz, gipotonus, depression of consciousness up to coma.

Treatment: discontinuation of the drug, simptomaticheskaya therapy.

Dosing and Administration.

Tablets should dissolve in the mouth until complete dissolution, moving it uniformly throughout the oral cavity in order to avoid damage to the mucosa at the site of absorption. Adults and children over 12 years - 8,75 mg (1 Table.) no more 5 times during 24 no. Tablets should not be used more 3 days.

Precautions.

If you want to determine the 17-ketosteroids drug should be discontinued for 48 h before the test. The period of application should refrain from activities potentially hazardous activities, requiring quick mental and physical reactions, as well as associated with high concentration of attention.

Cooperation