Amiodarone

When ATH:
C01BD01

Characteristic.

Crystalline powder, white or cream color. Slightly soluble in water, soluble in alcohol, very soluble in chloroform.

Pharmacological action.
Antiarrhythmic, antianginalnoe.

Application.

Severe arrhythmias (usually, with inefficiency or inability to other therapy): Atrial and ventricular premature beats, WPW-syndrome, atrial flutter and atrial fibrillation, ventricular tachycardia, ventricular fibrillation; Background arrhythmia or coronary heart failure, ventricular arrhythmias in patients with Chagas disease myocarditis.

Contraindications.

Hypersensitivity (incl. for iodine), sinusovaya bradycardia, OF блокада, sinus syndrome failure, expressed conduction disorders, cardiogenic shock, thyroid dysfunction.

Pregnancy and breast-feeding.

Category actions result in FDA - D. (There is evidence of the risk of adverse effects of drugs on the human fetus, obtained in research or practice, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk, if the drug is needed in life-threatening situations or severe disease, when safer agents should not be used or are ineffective.)

Side effects.

Mikrootsloyki retina, optic neuritis, Hyper- (It requires removal of the drug) or hypothyroidism, fibrosis lyegkikh, pneumonitis, pleurisy, bronhiolit, pneumonia, perifericheskie neuropathy and / or myopathies, extrapyramidal tremor, ataxia, cranial hypertension, nightmares, bradycardia, asistolija, OF блокада, nausea, vomiting, abnormal liver function, alopecia, epididymitis, anemia, photosensitivity, allergic reactions.

Cooperation.

Beta-blockers increase the risk of hypotension and bradycardia. Nesovmestim with BCC (It increases the likelihood of developing AV block and hypotension). Kolestiramin reduces T_1/2 level and Amiodarone plasma, cimetidine - uvelichivaet. Proximity effect anticoagulants, Digitalis preparations. Increasing the concentration of cyclosporine in the blood.

Overdose.

Symptoms: bradycardia, gipotenziya, OF блокада, electromechanical dissociation, cardiogenic shock, asistolija, cardiac arrest.

Dosing and Administration.

B /, loading dose - 5 mg / kg for 15 m 2-3 times per day, maintenance therapy - 10-20 mg / kg / day (250 ml 5% aqueous).

Inside, from 100 to 400 mg / day (the maximum dose - 600 mg / day) 8-10 days, possible break - 2 days per week.

Precautions.

Mandatory ECG monitoring. Do not combine with beta-blockers, verapamil, diltiazemom, laxatives, GI motility. The caution is combined with drugs, cause hypokalemia (Diuretic, corticosteroids, amphotericin B for the on / in the), and prescribed to patients with severe and prolonged diarrhea. Prolonged treatment is necessary observation ophthalmologist, regular monitoring of thyroid function, X-ray examination of lungs.

Cooperation