Nadolol

When ATH:
C07AA12

Characteristic.

The white crystalline powder. It is soluble in ethanol, hydrochloric acid, weakly in water and chloroform, poorly soluble in sodium hydroxide.

Pharmacological action.
Gipotenzivnoe, antianginalnoe, antiarrhythmic.

Application.

Arterial hypertension, angina, sinus tachycardia; prevention of paroxysmal supraventricular and ventricular arrhythmias, ʙigeminii, trigeminii; gipertroficheskaya cardiomyopathy, mitral valve prolapse, myocardial infarction (in clinically stable condition of the patient), hyperkinetic cardiac syndrome, tremor (essencialny), anxiety state (symptomatic treatment), migraine (prevention).

Contraindications.

Hypersensitivity, vыrazhennaya bradycardia (less 50 u. / min), AV block II-III degrees, sick sinus syndrome, cardiogenic shock, chronic and refractory to the treatment of severe heart failure, pulmonary heart disease, gipotenziya, obliterating vascular disease (Raynaud's syndrome), bronchial asthma (incl. history), lactation.

Restrictions apply.

The liver and kidneys, diabetes, gipoglikemiâ, hyperthyroidism, chronic obstructive pulmonary disease, otyahoschennыy allerholohycheskyy history, the elderly and children's age.

Pregnancy and breast-feeding.

Maybe, if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Side effects.

From the nervous system and sensory organs: feeling tired, headache, sleep disturbance and speech, paresthesia, visual disturbances, decreased libido.

From the respiratory system: nasal congestion, cough, rarely, bronchospasm.

Cardio-vascular system and blood (hematopoiesis, hemostasis): bradycardia, OF блокада, gipotenziya, heart failure, cold extremities.

From the digestive tract: dry mouth, anorexia, nausea, vomiting, dyspepsia, flatulence, diarrhea or constipation.

Other: impotence, rash, prurigo, dryness of the eyes and skin, hyperhidrosis, swelling of the face, alopecia, weight change.

Cooperation.

It should not be used simultaneously with MAO inhibitors. Dihydropyridine calcium antagonists, simpatolitiki, peripheral vasodilators, Diuretic potenciruet gipotenziю; эпинефрин и изопреналин — ослабляют. Chance of violations of automaticity, conduction and cardiac contractility increases against the backdrop of amiodarone, diltiazema, verapamil, quinidine drugs and general anesthetics.

Overdose.

Symptoms: dizziness, bradycardia, arrhythmia, gipotenziya, difficulty breathing, acrocyanosis, heart failure, in severe cases - collapse.

Treatment: hemodialysis, atropine (I / 0.25-1 mg), beta-agonists (Isoprenaline), trankvilizatorov (diazepam, Lorazepam), kardiotonikov (doʙutamin, Dopamine, epinephrine, norepinephrine, cardiac glycosides), diuretics, etc.. symptomatic treatment.

Dosing and Administration.

Inside, regardless of the meal. Angina, Arrhythmia, мигрени — 40 mg 1 once a day, if necessary, increase the dose (1 once a week) при стенокардии до 120–160 мг/сут, аритмии до 160 мг/сут и мигрени до 80–160 мг/сут. При артериальной гипертензии — 80–240 мг, single. При гипертиреозе — 80–160 мг в сутки. При нарушении функции почек интервал между приемами при Cl креатинина 50 мл/мин должен составлять 20 no, 31–50 мл/мин — 24–36 ч, 10–30 мл/мин — 24–48 ч, 10 мл/мин — 40–60 ч.

Precautions.

Treatment stopped gradually over about 2 Sun (preventive withdrawal). Dosage adjustment is necessary in elderly patients. Mask symptoms of hypoglycemia (tachycardia, changes in blood pressure) and hyperthyroidism (tachycardia). Against the background of immunotherapy or aggravated allergic history, should be replaced by others. preparation of the pharmacological group (It increases the severity and duration of anaphylactic reactions to allergens, eliminates the effect of conventional doses of epinephrine). It should refrain from the use in pediatric practice, because the safety and efficacy of the children are not identified. It canceled a few days before surgery with the use of inhalation anesthesia (including surgical dentistry) or select an anesthetic with the least negative inotropic effects. In preparing the patient for a partial thyroidectomy for 10 days taken with potassium iodide. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention. At the time of treatment is recommended to eliminate the use of alcohol.

Cautions.

During treatment may change the test results in laboratory studies.