Benzathines benzilpenicillin

When ATH:
J01CE08

Characteristic.

Natural antibiotic penicillin group of prolonged action.

White powder, odorless and tasteless, is formed when adding water resistant suspension. Practically insoluble in water, little - in alcohol.

Pharmacological action.
Antibacterial, bactericide.

Application.

Infectious diseases, caused by susceptible microorganisms (especially if required long-term maintenance of therapeutic concentrations), incl. Treponema (syphilis, frambeziya, pint), beta-hemolytic streptococcus (pharyngitis, mug, scarlet fever, quinsy, wound infections), prevention of post-operative complications, prevention of recurrences of rheumatic fever.

Contraindications.

Hypersensitivity, incl. other penicillins, bronchial asthma, pollen disease, propensity to allergic reactions.

Side effects.

Allergic reactions: rash on the skin and mucous membranes, hives, fever, eozinofilija, joint pain, erythema multiforme, exfoliative dermatitis, angioedema, anaphylactic shock.

Cardio-vascular system and blood (hematopoiesis, hemostasis): anemia, thrombocytopenia, leukopenia, coagulation disorders.

Other: headache, stomatitis, glossitis; Local events: pain at the injection site, infiltrates, abscesses, CVIS, peripheral neuritis; With prolonged therapy - superinfection, caused by drug-resistant organisms and fungi.

Cooperation.

Bactericidal antibiotics (incl. cephalosporins, cycloserine, vancomycin, rifampicin, aminoglikozidy) exert a synergistic effect, bacteriostatic (incl. makrolidы, chloramphenicol, lincosamides, tetracikliny) - Antagonistic. Improves the effectiveness of indirect anticoagulants. Reduces the effectiveness of oral contraceptives and ethinyl estradiol (the risk of breakthrough bleeding). Diuretic, allopurinol, NSAIDs - reduce tubular secretion and increase concentration. Allopurinol increases the risk of allergic reactions (skin rash).

Dosing and Administration.

/ M. Adults for the prevention and treatment of infectious diseases at a dose of 300,000-600,000 1 weekly or 1,2 MU (In the treatment of rheumatism - before 2,4 MU) 2 once a month. For the prevention of relapse of rheumatism - 600000 ED 1 once a week for 6 weeks in combination with taking aspirin or other NSAIDs. Children are introduced at the rate of 5000–10000 units/kg 1 once a week or based 20000 U / kg 2 once a month (more frequent injections are not allowed). Treatment for syphilis is carried out by a special instruction. The average dose - 2,4 Milln IC 2-3 times with interval 8 days.

Precautions.

Enter must be strictly / m to a considerable depth, before the injection is carried out aspirate. When injected into the blood vessels may develop ischemia and embolism. If necessary, they do two injections in different buttocks. When the blood in the syringe during / m injection (It indicates the needle enters a blood vessel) should be removed and make an injection syringe to another location. After injection of the injection site press down with a cotton swab, that prevents drugs from the muscle tissue in the subcutaneous tissue (rubbing the buttocks after the injection is not recommended).

In case of accidental intravascular injection can be marked transient feeling of oppression, anxiety and impaired vision (syndrome Uane).

With the development of allergic reaction stop treatment immediately. At the first signs of anaphylactic shock is necessary to take urgent measures to bring the patient out of this state: a norepinephrine, glucocorticoids et al., if necessary - IVL.

In the treatment of sexually transmitted diseases, if there is a suspicion of syphilis, before therapy and then for 4 months necessary to conduct microscopic and serology.

Due to the possibility of fungal infections, the advisability of Nystatin and levorin. Because, that prolonged oral antibiotics can be inhibited intestinal microflora, produce vitamin B₁, IN₆, IN₁₂, patients for the prevention of vitamin deficiencies advisable to appoint B vitamins. It is necessary to take into account, that the use of the drug in doses insufficient or too early termination of treatment often leads to the emergence of resistant strains of pathogens.

Cooperation

Active substance	Description of interaction
Amiodarone	FKV. Increases of the free fraction in plasma (as having a greater ability to bind to proteins to displace fixation locations).
Amitriptyline	FKV. Increases of the free fraction in plasma (as having a greater ability to bind to proteins to displace fixation locations).
Warfarin	FKV. Increasing the concentration of the free fraction in plasma (displaces the binding sites on proteins).
Glipizide	FKV. Increases of the free fraction in plasma, since, having a greater ability to bind to proteins, displaces from places fixing.
Diazepam	FKV. Increases of the free fraction in plasma (It has a greater ability to bind to plasma proteins and to displace fixation locations).
Diclofenac	FKV. Increases of the free fraction of blood (displaces the binding sites on plasma proteins).
Diclofenac potassium	FKV. Increases of the free fraction of blood (displaces the binding sites on plasma proteins).
Dipiridamol	FKV. Increases of the free fraction in plasma (displace from its association with proteins).
Doxycycline	FMR: antagonizm. Weakens bactericidal effect (stops bacterial growth).
Ibuprofen	FKV. Increases of the free fraction of blood (displaces the binding sites on plasma proteins).
Imipramine	FKV. Increases of the free fraction in plasma.
Indomethacin	FKV. Increases of the free fraction in plasma (displaces the binding sites on proteins).
Ketoprofen	FKV. Increases of the free fraction of blood (displace from its association with plasma proteins).
Ketorolac	FKV. Increases of the free fraction of blood (displace from its association with plasma proteins).
Klozapyn	FKV. Increases of the free fraction in plasma, since, having a greater ability to bind to proteins, displaces from places fixing.
Clomipramine	FKV. Increases of the free fraction in plasma, since, having a greater ability to bind to proteins, displaces from places fixing.
Methotrexate	FKV. FMR. Against the background of benzathine penicillin reduced excretion and increased risk of toxic effects.
Midazolam	FKV. Increases of the free fraction in plasma (displaces penicillin binding sites on proteins).
Naproxen	FKV. Increases of the free fraction of blood (displace from its association with plasma proteins).
Oxazepam	FKV. With greater ability to bind to plasma proteins, increases the concentration of the free fraction in plasma (displaces from places fixing).
Oxytetracycline	FMR: antagonizm. Weakens bactericidal effect (stops bacterial growth).
Ornithine	FV. Solutions can not be mixed "in the same syringe".
Piroxicam	FKV. Increases of the free fraction of blood (displace from its association with plasma proteins).
Propranolol	FKV. Increases of the free fraction in plasma, since, having a greater ability to bind to proteins, displaces from places fixing.
Tetracycline	FMR: antagonizm. Weakens bactericidal effect (stops bacterial growth).
Phenylbutazone	FKV. Increases of the free fraction in plasma (displaces the binding sites on proteins).
Flurbyprofen	FKV. Increases of the free fraction of blood (displace from its association with plasma proteins).
Xlordiazepoksid	FKV. With greater ability to bind to plasma proteins, increases the concentration of the free fraction in plasma (displaces from places fixing).
Chlorpromazine	FKV. Increases of the free fraction in plasma, since, having a greater ability to bind to proteins, displaces from places fixing.
Celecoxib	FKV. Increases of the free fraction in plasma (displaces the binding sites on proteins).
Cyclosporine	FKV. Increases of the free fraction in plasma, since, having a greater ability to bind to proteins, displaces from places fixing.
Erythromycin	FMR: antagonizm. Weakens bactericidal effect (shows in vitro).