Benzathines benzilpenicillin

When ATH:
J01CE08

Characteristic.

Natural antibiotic penicillin group of prolonged action.

White powder, odorless and tasteless, is formed when adding water resistant suspension. Practically insoluble in water, little - in alcohol.

Pharmacological action.
Antibacterial, bactericide.

Application.

Infectious diseases, caused by susceptible microorganisms (especially if required long-term maintenance of therapeutic concentrations), incl. Treponema (syphilis, frambeziya, pint), beta-hemolytic streptococcus (pharyngitis, mug, scarlet fever, quinsy, wound infections), prevention of post-operative complications, prevention of recurrences of rheumatic fever.

Contraindications.

Hypersensitivity, incl. other penicillins, bronchial asthma, pollen disease, propensity to allergic reactions.

Side effects.

Allergic reactions: rash on the skin and mucous membranes, hives, fever, eozinofilija, joint pain, erythema multiforme, exfoliative dermatitis, angioedema, anaphylactic shock.

Cardio-vascular system and blood (hematopoiesis, hemostasis): anemia, thrombocytopenia, leukopenia, coagulation disorders.

Other: headache, stomatitis, glossitis; Local events: pain at the injection site, infiltrates, abscesses, CVIS, peripheral neuritis; при длительной терапии — суперинфекция, caused by drug-resistant organisms and fungi.

Cooperation.

Bactericidal antibiotics (incl. cephalosporins, cycloserine, vancomycin, rifampicin, aminoglikozidy) exert a synergistic effect, bacteriostatic (incl. makrolidы, chloramphenicol, lincosamides, tetracikliny) — антагонистическое. Improves the effectiveness of indirect anticoagulants. Reduces the effectiveness of oral contraceptives and ethinyl estradiol (the risk of breakthrough bleeding). Diuretic, allopurinol, НПВС — снижают канальцевую секрецию и повышают концентрацию. Allopurinol increases the risk of allergic reactions (skin rash).

Dosing and Administration.

/ M. Взрослым для профилактики и лечения инфекционных заболеваний в дозе 300000–600000 ЕД 1 weekly or 1,2 MU (при лечении ревматизма — до 2,4 MU) 2 once a month. Для профилактики рецидивов ревматизма — 600000 ED 1 once a week for 6 weeks in combination with taking aspirin or other NSAIDs. Детям вводят из расчета 5000–10000 ЕД/кг 1 раз в неделю или из расчета 20000 U / kg 2 once a month (more frequent injections are not allowed). Treatment for syphilis is carried out by a special instruction. The average dose - 2,4 млн ЕД 2–3 раза с интервалом 8 days.

Precautions.

Enter must be strictly / m to a considerable depth, before the injection is carried out aspirate. When injected into the blood vessels may develop ischemia and embolism. If necessary, they do two injections in different buttocks. When the blood in the syringe during / m injection (It indicates the needle enters a blood vessel) should be removed and make an injection syringe to another location. After injection of the injection site press down with a cotton swab, that prevents drugs from the muscle tissue in the subcutaneous tissue (rubbing the buttocks after the injection is not recommended).

In case of accidental intravascular injection can be marked transient feeling of oppression, anxiety and impaired vision (syndrome Uane).

With the development of allergic reaction stop treatment immediately. At the first signs of anaphylactic shock is necessary to take urgent measures to bring the patient out of this state: a norepinephrine, glucocorticoids et al., if necessary - IVL.

In the treatment of sexually transmitted diseases, if there is a suspicion of syphilis, before therapy and then for 4 months necessary to conduct microscopic and serology.

Due to the possibility of fungal infections, the advisability of Nystatin and levorin. Because, that prolonged oral antibiotics can be inhibited intestinal microflora, produce vitamin B₁, IN₆, IN₁₂, patients for the prevention of vitamin deficiencies advisable to appoint B vitamins. It is necessary to take into account, that the use of the drug in doses insufficient or too early termination of treatment often leads to the emergence of resistant strains of pathogens.

Cooperation