Voʙenzim: instructions for using the medicine, structure, Contraindications

Active material: Combined preparation
When ATH: M09AB52
CCF: The drug with anti-inflammatory and immunomodulatory effects
ICD-10 codes (testimony): B15, B16, B17.1, B18.1, B18.2, E06, G35, H36.0, i20, I21, I70, I73.1, I79.2, I80, I87.0, I89.0, J01, J15, J20, J32, J42, K73, K86.1, L20.8, L70, M02, M05, M08, M45, N00, N03, N10, N11, N30, N41, N60, N70, T14, T14.1, T14.3, T30, Z29.8, Z51.8
When CSF: 05.03.01
Manufacturer: MUCOS PHARMA GmbH&Co (Germany)

Voʙenzim: dosage form, composition and packaging

◊ Pills, enteric coated red-orange color, round, lenticular, with smooth surface, with a characteristic odor; permitted variations in the color intensity of the outer shell from red-orange to red color.

Excipients: lactose, corn starch, magnesium stearate, stearic acid, Purified water, colloidal silicon dioxide, talc, sucrose.

The composition of the shell tablets: sucrose, talc, a copolymer of methacrylic acid and methylmethacrylate, shellac, Titanium dioxide, White clay, dye yellow-orange (E110), Ponceau 4R dye (E124), povidone, macrogol 6000, triэtiltsitrat, vanillin, Wax Bleached, carnauba wax.

20 PC. – blisters (2) – packs cardboard.
20 PC. – blisters (10) – packs cardboard.
800 PC. – bottles of high density polyethylene.

Voʙenzim: pharmachologic effect

Combined preparation. It is a combination of highly active enzymes of plant and animal origin. Provides immunomodulatory, anti-inflammatory, fibrinolytic, decongestant, antiplatelet and secondary analgesic effect.

Wobenzym has a positive impact on the course of the inflammatory process, It limits the pathological manifestations of autoimmune and immunocomplex processes, a positive effect on performance immunological reactivity. It stimulates and regulates the functional activity of monocytes, macrophages,, natural killer, stimulate anti-tumor immunity, Cytotoxic T lymphocytes, phagocytic activity of cells.

Under the influence of Wobenzym decreases the amount of circulating immune complexes and excretion occurs membrane deposits of immune complexes of fabrics.

Wobenzym reduces the interstitial infiltration of plasma cells. Increases elimination of protein detritus and fibrin deposits in the area of ​​inflammation, It accelerates lysis of toxic products of metabolism and dying tissue, improves the resorption of hematomas and swelling, normalizes permeability of vessel walls.

Wobenzym reduces the concentration of thromboxane and platelet aggregation. Adjusts the adhesion of blood cells, enhances the ability of red blood cells change shape, adjusting their plasticity, normalizes the number of normal discocytes (Platelet) and reduces the total number of activated platelets forms, normalizes blood viscosity, reduces the total number of mikroagregantov, thereby improving microcirculation and blood rheology, as well as the supply of tissues with oxygen and nutrients.

Wobenzym normalize lipid metabolism, reduces the synthesis of endogenous cholesterol, increases the concentration of HDL, reduces atherogenic lipids, improves absorption of polyunsaturated fatty acids.

Wobenzym increases the effectiveness of antibiotic therapy, increasing the concentration of antibiotics in the blood plasma, and the focus of inflammation, and reduces the side effects of antibiotics (dysbiosis).

Wobenzym reduces the severity of side effects, associated with hormonal drugs (incl. hypercoagulability).

Wobenzym regulatory mechanisms of nonspecific protection (production of interferon), thereby demonstrating antiviral and antimicrobial effect.

Voʙenzim: pharmacokinetics

Upon receiving Wobenzym inside a part of the enzyme preparation are absorbed from the small intestine by resorption of intact molecules and, binding to transport proteins of blood, enter the bloodstream. Then enzymes, migrating on the vascular bed, It accumulates in the area of ​​pathological process.

Voʙenzim: testimony

In the combined therapy:

• thrombophlebitis (incl. acute thrombophlebitis of superficial veins), postflebitichesky syndrome, occlusive disease and atherosclerosis of the arteries of the lower extremities, lymphoedema, prevention of recurrent phlebitis;
• cystitis, cystopyelitis, prostatitis;
• infection, Sexually Transmitted Infections;
• chronic genital infections, gestosis, mastitis, adnexitis, to reduce the frequency and severity of side effects of hormone replacement therapy in gynecology;
• angina, subacute stage of myocardial infarction (to improve the rheological properties of blood);
• sinusitis, bronchitis, pneumonia;
• pancreatitis, hepatitis;
• pyelonephritis, glomerulonephritis;
• diabetic angiopathy, diabeticheskaya retinopathy;
• autoimmune thyroiditis;
• rheumatoid arthritis, reactive arthritis, ankylosing spondylitis;
• atopic dermatitis, acne;
• multiple sclerosis;
• uveitis, iridocyclitis, hemophthalmus, used in ophthalmic surgery;
• treatment of postoperative complications (inflammatory processes, thrombosis, swelling), adhesive disease, and post-traumatic lymphoedema, plastic and reconstructive surgery;
• injury, fractures, distortion, damage ligamentous apparatus, injuries, Chronic post-traumatic processes, inflammatory soft tissue, burns, injuries in sports medicine.

Prevention:

• microcirculation disorders, poststressornyh violations, as well as the breakdown of adaptive mechanisms;
• side effects of hormone replacement therapy, hormonal contraception;
• in surgical interventions to prevent infectious complications and adhesive disease.

Wobenzym is recommended for prevention of infectious complications and improve quality of life during chemotherapy- or radiotherapy; viral infections and their complications.

Voʙenzim: dosing regimen

Establish individually, depending on the severity of the disease.

Adults depending on the activity and severity of disease are administered in a dose of 3 to 10 tab. 3 times / day. First 3 day dosing recommended dose is 3 tab. 3 times / day.

At average disease activity the drug is prescribed in a dose 5-7 tab. 3 times / day for 2 weeks. Subsequently, the dose should be reduced to 3-5 tab. 3 times / day. The course – 2 of the week.

At high disease activity the drug is prescribed in a dose 7-10 tab. 3 times / day for 2-3 weeks. Subsequently, the dose should be reduced to 5 tab. 3 times / day. The course – 2-3 Months.

At chronic diseases of long flowing Wobenzym can be used for indications of courses 3 to 6 months or more.

FROM to improve the efficacy of antibiotics and preventing dysbiosis Wobenzym should be used throughout the course of antibiotic therapy at a dose of 5 tab. 3 times / day. After the cessation of antibiotic therapy to restore the intestinal flora should be appointed by Wobenzym 3 tab. 3 times / day for 2 weeks.

During the radiotherapy and chemotherapy Wobenzym should be applied at a dose of 5 tab. 3 times / day until the completion of a course of radiotherapy and chemotherapy in order to prevent infection, improve basic treatment tolerability and quality of life.

FROM prophylactically Wobenzym appointed 3 tab. 3 times / day for 1.5 months with repetition rate 2-3 per year.

For children 5-12 years administered in a daily dose rate of 1 tab. on 6 kg body weight. Children over 12 years the drug is prescribed under the scheme, intended for adults. The duration of treatment is determined individually.

The drug should be taken at least 30 minutes before eating, without chewing, drinking water (200 ml).

Voʙenzim: side effects

Voʙenzim, usually, well tolerated by patients. In most cases, side effects, withdrawal, habituation was not observed even after prolonged use at high doses.

In some cases,: minor changes the consistency and smell of feces, hives (tested at lower doses or discontinuation of therapy).

The patient should be warned, that the appearance of other adverse reactions should be repealed taking the drug and seek medical advice.

Voʙenzim: Contraindications

• disease, associated with an increased chance of bleeding (incl. hemophilia, thrombocytopenia);
• hemodialysis;
• Children up to age 5 years;
• individual intolerance to the drug.

Voʙenzim: Pregnancy and lactation

With caution and under medical supervision should be given Wobenzym during pregnancy and lactation.

Voʙenzim: Special instructions

It should be taken into account, that at the beginning of treatment Wobenzym may increase symptoms. In such cases it is advisable to temporarily reduce the dose, Treatment should not be interrupted.

When infectious and inflammatory diseases Wobenzym does not replace antibiotic treatment, but increases their efficiency.

Wobenzym is not a doping.

Effects on ability to drive vehicles and management mechanisms

The drug has no negative impact on the ability to drive a car and perform work, requiring a high rate of psychomotor reactions.

Voʙenzim: overdose

No cases of overdose were reported Wobenzym.

Voʙenzim: drug interaction

When concomitantly Wobenzym with other drugs known incompatibilities.

Voʙenzim: terms of dispensing from pharmacies

The drug is resolved to application as an agent Valium holidays.

Voʙenzim: terms and conditions of storage

List B. The drug should be stored out of reach of children, dry place with a temperature of 15 ° to 25 ° C. Shelf life – 2.5 year.