Morphine
When ATH:
N02AA01
Cooperation
| Active substance | Description of interaction |
| Amitriptyline | FKV. FMR. It increases the bioavailability and degree of analgesia. |
| Acetylsalicylic acid | FMR. Increases the incidence of myoclonus, caused by high doses of morphine. |
| Haloperidol | FMR. May increase the incidence of myoclonus, caused by high doses of morphine. |
| Diclofenac | FKV. It enhances the analgesic effect and increases the risk of respiratory depression and the possibility of other side effects. |
| Domperidone | FMR. Against the background of morphine attenuated effects on the gastrointestinal tract. |
| Zidovudine | Against the background of morphine reduces clearance and increases the risk of toxic effects. |
| Indomethacin | It enhances the analgesic effect and increases the risk of myoclonus due to high doses of morphine. |
| Ketamine | FMR: synergism. Strengthens (mutually) effect (incl. respiratory depression). |
| Ketoprofen | FMR: antagonizm. It may reduce the effect of respiratory depression. |
| Clomipramine | FKV. FMR. It increases the bioavailability and degree of analgesia. |
| Lidokain | Perhaps greater analgesic effect. |
| Metoclopramide | FKV. FMR: synergism. It increases the absorption rate of ingestion and enhances sedation. |
| Naproxen | FMR. Possible increased risk of myoclonus due to high doses of morphine. |
| Piroxicam | FMR. Possible increased risk of myoclonus due to high doses of morphine. |
| Propranolol | FMR. When combined lethal dose of morphine and propranolol significantly reduced for animals. |
| Ranitidine | It can change the enterohepatic circulation; while the appointment should be closely monitored. |
| Rifampicin | FKV. FMR. Accelerates biotransformation, weakens effects. |
| Selegiline | Against the background of morphine may be fever and a toxic effect on the central nervous system. |
| Fluoxetine | FMR. May enhance the analgesic effect and reduce some of the side. |
| Chlorpromazine | FMR. May increase the incidence of myoclonus, caused by high doses of morphine. |
| Cyclosporine | Against the background of / in the morphine can develop (described a single case) insomnia, anxiety, amnesia, afazija, confusion. |
| Cyclophosphamide | Against the background of increasing morphine (It is shown in an animal study) toxicity. |
| Ciprofloxacin | FMR. Against the background of reduced plasma concentrations of morphine. |
| Esmolol | FKV. Against the background of increasing concentrations of morphine in plasma. |
| Ethanol | Increases (mutually) hypotensive and sedative effects. |
