Domperidone

When ATH:
A03FA03

Characteristic.

Prokinetic agents. Dopamine receptor antagonist.

Pharmacological action.
Prokinetic, antiemetic, normalizes the function of the digestive tract.

Application.

Diarrhoeal disorders against the background of delayed gastric emptying, gastroesophageal reflux disease: epigastric fullness, bloated feeling, pain in the upper abdomen, belching, flatulence, heartburn with or without reflux of stomach contents into the casting mouth. Nausea and vomiting of various origins (incl. amid functional and organic diseases, Infections, when toxemia, radiation therapy, Abuse diet, drug genesis, incl. when receiving dopamine agonists, levodopa, bromocriptine, during endoscopy and gastrointestinal radiocontrast studies); Ikotech, atonic gastrointestinal tract (incl. Postoperative); the need to accelerate peristalsis during gastrointestinal radiocontrast studies.

Contraindications.

Hypersensitivity, gastrointestinal bleeding, Mechanical bowel obstruction, perforation of the stomach or intestines (stimulation of peristalsis may aggravate these conditions), hyperprolactinemia, prolactinoma; Children up to age 5 years and children weighing up to 20 kg is for tablets.

Restrictions apply.

Renal and / or hepatic insufficiency, pregnancy, lactation.

Pregnancy and breast-feeding.

Maybe, if the effect of therapy outweighs the potential risk to the fetus and child (studies in pregnant women have not held, low concentrations of domperidone are found in the breast milk of women).

Side effects.

From the digestive tract: spasm of smooth muscles of the digestive tract, dry mouth, stomatitis, thirst, heartburn, change in appetite, constipation / diarrhea.

From the nervous system and sensory organs: extrapyramidal disorder (in children and patients with increased permeability of the BBB), headache, asthenia, irritability, nervousness, drowsiness, leg cramps, lethargy, conjunctivitis (itch, Krasnoja, pain, eye puffiness).

Allergic reactions: skin rash, itch, hives, edema (person, hands, shins or feet).

Other: increase the level of prolactin in blood plasma, galactorrhea, gynecomastia, menstrual disorders, mastalgïya, the change in frequency of urination, dizurija (burning, difficulty and pain when urinating), heartbeat.

Cooperation.

Antacids and antisecretory drugs reduce the bioavailability, anticholinergics weaken the effect of domperidone. Ингибиторы изофермента CYP3A4 цитохрома P450 (azole antifungals, macrolide antibiotics, HIV protease inhibitors) may block the metabolism of domperidone and increase its level in plasma (joint application requires diligence). With care to apply concurrently with MAO inhibitors. It is possible the impact on the absorption of the drugs at the same time a sustained release of the active substance. Domperidone not affect the level of paracetamol in the blood and digoxin.

Overdose.

Symptoms: drowsiness, arrhythmia, disorientation, extrapyramidal disorder (especially in children), decrease in blood pressure.

Treatment: activated carbon, When an extrapyramidal reactions — antiholinergicakie means or antihistamines with antiholinergicheskoj activity, preparations, used to treat Parkinson's disease. No specific antidote.

Dosing and Administration.

Inside, 15-30 minutes before eating. Adults-on 10 mg 3-4 times a day, if necessary, increase the dose to 60 mg / day. The dose for children are calculated according to body weight.

Precautions.

There should be appointed for the prevention of postoperative vomiting.