Methoxsalen

When ATH:
D05BA02

Characteristic.

Isolated from the seeds of Ammi majus. It refers to psoralen.

Pharmacological action.
Photosensitizing.

Application.

Sensitization UV radiation at a psoriasis (when the diagnosis is confirmed by biopsy results), vitiligo, lichen planus, fungous athlete.

Contraindications.

Hypersensitivity (incl. other psoralens), increased photosensitivity (systemic lupus erythematosus, porphyria, Kaposi's disease, albinism), melanoma (incl. history), afakija, childhood and adolescence (to 12 years).

Restrictions apply.

Liver disease, Cardiovascular, pregnancy, lactation.

Side effects.

Nausea, эritema, itch. With prolonged use at high doses may cause symptoms of skin aging, cataracts and carcinomas.

Cooperation.

Strengthens (mutually) photosensitizing effect (should not be administered together) Anthralin, tar and its derivatives, griseofulvin, phenothiazine, nalidixic acid, quinolones and fluoroquinolones, halogenated salicylanilides (bacteriostatic soaps), sulfonamydov, tetracyclines, tiazidov, organic dyes (methylene blue, toluidine blue and others.).

Overdose.

In the case of intentional or accidental poisoning is necessary to induce vomiting (в первые 2–3 ч после приема), put the patient into a dark room (at least 24 no).

Dosing and Administration.

За 1,5–2 ч до сеанса УФ-облучения. Dose selected individually depending on the patient's body weight.

Precautions.

Не следует принимать солнечные ванны за 24 ч до приема метоксалена и последующей фототерапии. После приема рекомендуется носить солнцезащитные очки в течение 24 no (to prevent the development of cataracts) и избегать воздействия солнечных лучей в течение 8 no. During the session, the patient should be irradiation in sunglasses, only 1/3 prescribed dose of radiation should affect the skin of the abdomen, Breast, genitals.

Cooperation