Methoxsalen

When ATH:
D05BA02

Characteristic.

Isolated from the seeds of Ammi majus. It refers to psoralen.

Pharmacological action.
Photosensitizing.

Application.

Sensitization UV radiation at a psoriasis (when the diagnosis is confirmed by biopsy results), vitiligo, lichen planus, fungous athlete.

Contraindications.

Hypersensitivity (incl. other psoralens), increased photosensitivity (systemic lupus erythematosus, porphyria, Kaposi's disease, albinism), melanoma (incl. history), afakija, childhood and adolescence (to 12 years).

Restrictions apply.

Liver disease, Cardiovascular, pregnancy, lactation.

Side effects.

Nausea, эritema, itch. With prolonged use at high doses may cause symptoms of skin aging, cataracts and carcinomas.

Cooperation.

Strengthens (mutually) photosensitizing effect (should not be administered together) Anthralin, tar and its derivatives, griseofulvin, phenothiazine, nalidixic acid, quinolones and fluoroquinolones, halogenated salicylanilides (bacteriostatic soaps), sulfonamydov, tetracyclines, tiazidov, organic dyes (methylene blue, toluidine blue and others.).

Overdose.

In the case of intentional or accidental poisoning is necessary to induce vomiting (in the first 2–3 hours after administration), put the patient into a dark room (at least 24 no).

Dosing and Administration.

1.5–2 hours before the UV irradiation session. Dose selected individually depending on the patient's body weight.

Precautions.

Sunbathing should not be done during 24 h before taking methoxalen and subsequent phototherapy. After administration, it is recommended to wear sunglasses for 24 no (to prevent the development of cataracts) and avoid exposure to sunlight during 8 no. During the session, the patient should be irradiation in sunglasses, only 1/3 prescribed dose of radiation should affect the skin of the abdomen, Breast, genitals.

Cooperation