Gliclazide

When ATH:
A10BB09

Characteristic.

Sulfonylurea derivative II generation.

Pharmacological action.
Hypoglycemic.

Application.

Diabetes mellitus type 2, monotherapy and in combinations insulin or other oral hypoglycemic agents.

Contraindications.

Hypersensitivity, diabetes mellitus type 1, incl. juvenile, Ketoacidosis, Diabetic (with ketoacidosis) and giperosmolyarnaya coma, extensive trauma and burns, hepatic failure and severe renal insufficiency, Hypo- and hyperthyroidism, pregnancy, lactation.

Restrictions apply.

Childhood (efficacy and safety of children are not identified).

Pregnancy and breast-feeding.

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects.

From the digestive tract: rarely diarrhoeal phenomenon (nausea, vomiting, abdominal pain), very rarely is jaundice.

Cardio-vascular system and blood: reversible cytopenia, eozinofilija, anemia.

For the skin: rarely - allergic skin reactions, photosensitivity.

Metabolism: gipoglikemiâ.

From the nervous system and sensory organs: weakness, headache, dizziness, change in taste.

Cooperation.

Effect increase ACE inhibitors, anabolic steroid, beta-blockers, fibrates, ʙiguanidы, chloramphenicol, cimetidine, kumarinы, fenfluramin, fluoxetine, salicilaty, guanethidine, MAO inhibitors, mikonazol, fluconazole, pentoxifylline, theophylline, phenylbutazone, fosfamidы, tetracikliny.

Barbiturates, chlorpromazine, glucocorticoids, sympathomimetic, glucagon, saluretiki, rifampicin, thyroid hormones, lithium salt, high doses of nicotinic acid, oral contraceptives and estrogen — weaken hypoglycemia.

Overdose.

Symptoms: hypoglycemic states, up to coma, swelling of the brain.

Treatment: receiving glucose inside, If necessary, in/with the introduction of glucose solution (50%, 50 ml). Monitoring of glucose levels, BUN, serum electrolytes. In oteke brain-mannit (I /), Dexamethasone.

Dosing and Administration.

Inside, for 30 minutes before or during meals. Therapeutic dose is 40-320 mg (depending on the level of glycemia). At the beginning of 40-160 mg morning, then before 320 mg / day. Doses, exceeding 160 mg, administered in divided doses (least 2). In combination with insulin during the day is recommended 60-180 mg.

The modified-release tablet: the initial dose - 30 mg; further dose increase can not earlier than 2 Sun; The maximum daily dose - 120 mg (1 once a day during breakfast).

Precautions.

During titration, especially in combination with insulin, necessary to determine the profile and dynamics of the sugar glucose, further shows regular monitoring of blood glucose. For the prevention of hypoglycemia should be clearly timed the drug to food intake, avoid starvation and to completely abandon the use of alcohol. Concomitant use of beta-blockers may mask the symptoms of hypoglycemia. It is recommended to stick to a low calorie diet low in carbohydrates. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cooperation