A nicotinic acid (When ATH C04AC01)

When ATH:
C04AC01

Characteristic.

The white crystalline powder;, slightly acidic taste. It is soluble in cold water (1:70), better in hot (1:15), slightly soluble in ethanol, очень мало — on the air.

Pharmacological action.
Makes up for the deficiency of vitamin PP (B₃), vazodilatirtee, gipolipidemicescoe, hypocholesteremic.

Application.

Prevention and treatment of pellagra (авитаминоз PP); atherosclerosis, hyperlipidemia (incl. hypercholesterolemia, hypertriglyceridemia), spasm of peripheral vessels, incl. occlusive disease, Raynaud's disease, migraine, cerebrovascular accident, including ischemic stroke (Combination Therapy), angina, disease Hartnapa, hypercoagulation, neuritis of the facial nerve, intoxication nonhealing wounds, ulcers, infectious diseases, gastrointestinal diseases.

Contraindications.

Hypersensitivity, gastric ulcer and duodenal ulcer (in the acute phase), expressed human liver, gout, hyperuricemia, severe hypertension and atherosclerosis (in / introduction).

Restrictions apply.

Pregnancy, lactation.

Pregnancy and breast-feeding.

With care during pregnancy and breastfeeding (high doses is contraindicated).

Side effects.

Conditional release of histamine: erythema, incl. face and upper body with a feeling of tingling and burning sensations, feeling a rush of blood to the head, dizziness, gipotenziya, orthostatic hypotension (With the rapid on / in a), increased secretion of gastric juice, itch, dyspepsia, hives.

With prolonged use of high doses: diarrhea, anorexia, vomiting, abnormal liver function, fatty liver, ulceration of the gastric mucosa, arrhythmia, paraesthesia, hyperuricemia, reduced glucose tolerance, giperglikemiâ, transient elevation of AST, LDH, alkaline phosphatase, irritation of the gastrointestinal mucosa.

Cooperation.

Potentiates the effect of fibrinolytic agents, antispasmodics and cardiac glycosides, toxic effect of alcohol on the liver. It reduces the absorption of bile acid sequestrants (requires interval in 1.5-2 hours between meals) and hypoglycemic effect of antidiabetic drugs. Possible interaction with antihypertensive drugs, acetylsalicylic acid, anticoagulants.

Dosing and Administration.

Inside (after meal), I / slowly, / m, n / a. For prevention: inside, adults — 0.0125-0.025 g/d, children on 0.005-0.025 g/day.

When pellagra: adults-inwards, by 0,1 g 2-4 times a day for 15-20 days or/in on 0,05 g or/m 0,1 g, 1-2 Times a day for 10-15 days; children — inside, -0.05 g 0.0125 to 2-3 times a day.

In ischemic stroke: I /, 0,01-0.05 g.

Atherosclerosis: inside, 2-3 g/day 2-4 reception.

When lipid metabolism disorders: inside, gradually increase the dose (in the absence of side effects) from 0,05 g 1 every day up to 2-3 g/day in a few receptions, a course of treatment - 1 months or more, between repeated courses needed breaks.

In other diseases: inside, adults-to 0.02-0.05 g (to 0,1 g) 23 times per day, children — by 0.025, 0.0125-2-3 times a day.

Precautions.

During treatment should regularly monitor liver function (especially when high doses). For the prevention of hepatotoxicity is necessary to include in the diet products, methionine rich (cottage cheese), or the appointment of methionine or other lipotropics.

Be wary of giperatsidnom gastritis, gastric ulcer and duodenal ulcer (in remission) because of irritation to the mucous membrane (taking high doses in which case contraindicated). Taking large doses it is also contraindicated in diseases of the liver, incl. gepatite, цirroze (Chance of hepatotoxicity), diabetes.

It is not appropriate to apply for the correction of dyslipidemia in patients with diabetes.

It should be taken into account, that p / and / m injections are painful.