Glucagon

When ATH:
H04AA01

Characteristic.

Hormone, produced by the alpha cells of the islets of Langerhans; derived from the pancreas of pigs or cattle. Crystalline white powder, comprising at least 0,05% Zinc. Practically insoluble in water; readily soluble at a pH below 3 and higher 9,5.

Pharmacological action.
Hyperglycemic, antispasmodic.

Application.

Gipoglikemiâ, gipoglikemicheskaya coma, X-rays of the gastrointestinal tract with barium under artificial hypotension, angiography, CT scan, nuclear magnetic resonance, diagnosis of bleeding from the small intestine using technetium labeled erythrocytes, hysterosalpingography, intoxication of beta-blockers and calcium antagonists, obstruction of esophagus by foreign bodies.

Contraindications.

Hypersensitivity, giperglikemiâ, insulinoma (may develop paradoxical hypoglycemic reactions), pheochromocytoma (stimulating the release of catecholamines in the blood, can cause hypertension), allergy to pork and / or beef proteins.

Pregnancy and breast-feeding.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

Side effects.

Nausea, anacatharsis, Symptoms of hypokalemia (severe muscle weakness, anorexia, Arrhythmia, myalgia, seizures of individual muscle groups), degidratatsiya, allergic reactions (dizziness, photophobia, skin rash and itching, respiratory failure).

Cooperation.

Proximity effect anticoagulants.

Overdose.

The symptom includes uncontrollable vomiting, signs of hypokalemia (severe muscle weakness, anorexia, Arrhythmia, myalgia, seizures of individual muscle groups) and dehydration.

Treatment: symptomatic with constant monitoring of the content of potassium in the blood. In the case of uncontrollable vomiting held rehydration of the patient and filling potassium loss.

Dosing and Administration.

Gipoglikemiâ: I /, / m or n / a administered 0.5-1 mg (if necessary - through 12 min repeat).

Intoxication beta adrenoblokatorami: infusion calculation of 0,005-0,15 mg / kg, then / drip at a rate of 1-5 mg per hour.

Intoxication antagonistami kalytsiya: single I / dose 2 mg, maintenance doses are selected individually depending on the patient's condition.

Esophageal foreign body obstruction: I / 0,5-2 mg (if necessary - again after 10-12 min).

Children: relief of hypoglycemia is made I /, / m or n / a dose 0,025 mg / kg body weight, but not more 1 mg (if necessary - through 12 min repeat).

Cooperation