Moksonidin

When ATH:
C02AC05

Pharmacological action.

Antigipertenzivnoe.

Application.

Arterial hypertension.

Contraindications.

Hypersensitivity, sick sinus syndrome, violation sinoatrial and AV conduction II-III degree, bradycardia me 50 bpm, severe cardiac arrhythmias, heart failure (III and IV NYHA functional class), angioedema in history, unstable angina, expressed human liver and / or kidney, peripheral circulatory disorders (obliterating atherosclerosis of the lower extremities with intermittent claudication syndrome, Raynaud's disease), Parkinson's disease, depression, epilepsy, glaucoma, pregnancy, lactation, Age to 16 years.

Pregnancy and breast-feeding.

Clinical data about the negative impact on the course of pregnancy is not. However, caution should be exercised, moxonidine assigning pregnant women. During treatment should stop breastfeeding (It passes into breast milk).

Side effects.

Dry mouth, fatigue, asthenia, headache, dizziness, sleep disturbance, drowsiness, orthostatic hypotension, peripheral edema.

Cooperation.

Strengthens (mutually) the effect of other antihypertensive drugs, deprimiruyuschie funds (alcohol, anxiolytics, barbiturates, neuroleptics). Tricyclic antidepressants may decrease the effectiveness of antihypertensive drugs of the central action.

Overdose.

Symptoms: excessively pronounced decrease in blood pressure, dry mouth, heartbeat, weakness, drowsiness.

Treatment: symptomatic. As a specific antidote is administered idazoxan (imidazoline antagonist).

Dosing and Administration.

Inside, during or after a meal, the initial dose 0,2 mg 1 once a day, the maximum single dose 0,4 mg, the maximum daily dose 0,6 mg, razdelennaya of 2 admission.

In patients with renal insufficiency (CL creatinine is 30-60 ml/min) and patients, hemodialysis, single dose not exceed 0,2 mg, The maximum daily dose - 0,4 mg.

Precautions.

If you need to cancel at the same time received β-blockers and moxonidine, first override β-adrenoreceptor antagonists and only a few days — moxonidine. Moxonidine can be administered with thiazide diuretics, ACE inhibitors and CCBs. Not recommended to prescribe tricyclic antidepressants concurrently with moxonidine.

During treatment requires regular monitoring of blood pressure, Heart rate and ECG. Stop taking Moxonidine should gradually.

Patients with rare hereditary pathology-Galactose intolerance, lactose deficiency or glucose-galactose malabsorption should not take this drug.

During treatment excludes alcohol, not recommended (especially at the beginning of treatment) using machinery, requiring special attention and speed of reaction.

Cooperation