Zopiclone

When ATH:
N05CF01

Characteristic.

Non-benzodiazepine hypnotic patterns (derivative tsiklopirrolona).

Pharmacological action.
Snotvornoe, sedation.

Application.

Infringement sleep (difficulty falling asleep, frequent night and / or early morning awakening), incl. situational, short, chronic insomnia; Secondary sleep disorders in psychiatric disorders.

Contraindications.

Hypersensitivity, severe respiratory failure, pregnancy (especially I and III trimester), lactation, Age to 18 years.

Restrictions apply.

Sleep apnea, myasthenia, severe hepatic insufficiency.

Pregnancy and breast-feeding.

Contraindicated in pregnancy (especially in the I and III trimester). When using zopiclone woman in the III trimester of pregnancy a newborn may be a violation of the nervous system, the occurrence of withdrawal syndrome. When, if a woman is prescribed by a doctor took zopiclone immediately prior to labor and delivery, It needs constant medical supervision for a newborn. At the time of treatment should stop breastfeeding (Zopiclone passes into breast milk).

Side effects.

From the nervous system and sensory organs: drowsiness, slackness, fatiguability, headache, dizziness, irritability, confusion (most often in the elderly), dejection, muscular weakness, dystaxia, diplopia, memory impairment, paradoxical reactions (strengthening of insomnia, nightmares, nervousness, excitation, aggressiveness, tantrums, hallucinations).

Other: bitter or metallic taste in the mouth, dry mouth, nausea, vomiting, allergic skin reactions, changes in libido, anterogradnaya amnesia.

There may be addictive, drug dependence, withdrawal, incl. rebound insomnia (cm. Precautions).

Cooperation.

When combined with other drugs zopiclone, CNS depressants (incl. neuroleptics, other hypnotics, antiepileptic drugs, some antihistamine drugs, alcohol) possible mutual reinforcement effects.

It reduces the concentration of zopiclone in plasma trimipramina.

Overdose.

Symptoms: CNS depression of varying severity (from drowsiness to unconsciousness).

Treatment: gastric lavage, administration of activated charcoal; if necessary - symptomatic therapy. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital). Hemodialysis nyeeffyektivyen.

Dosing and Administration.

Inside. The dose and duration of treatment is determined by the doctor strictly individual. The average dose is 7,5 mg dose, for the night, the maximum dose - 15 mg. Patients over 65 years, patients with liver disease or chronic respiratory insufficiency is recommended half dose (3,75 mg). A course of treatment: several days to 4 Sun.

Precautions.

Due to the possibility of development of drug dependence use for a long period may be assigned a doctor, in exceptional cases,. When, If insomnia persists for 4 Sun, should inform your doctor. The likelihood of addiction, physical or psychological dependence grows in violation of the prescribed dosage or length of treatment more 4 Sun.

Abolition should be gradual, tk. the sudden termination of the possibility of resuming treatment of insomnia, frequent awakenings, headache and muscle pain, anxiety, excitation, distraction, irritability.

Paradoxical reactions are more common in elderly patients. In the event of paradoxical reactions zopiclone should be abolished.

The next day, after taking zopiclone should avoid driving and Occupation potentially hazardous activities, require increased attention and quick response. During treatment, zopiclone should refrain from alcohol or drugs, containing alcohol.

Cooperation