Mianserin

When ATH: N06AX03

Characteristic.

Antidepressant chetyrehtsiklicheskoy structure.

The white crystalline powder;, solubility in water 1:50, alcohol 1:100, chloroform 1:20; pH 1% solution in the water-4.0-5.5, light sensitive.

Pharmacological action.
Antidepressant, sedation, snotvornoe.

Application.

Depressions of different genesis.

Contraindications.

Hypersensitivity, mania, severe liver, acute phase of myocardial infarction, pregnancy, lactation, Children and Youth age (to 18 years).

Side effects.

From the nervous system and sensory organs: drowsiness (in the early days of admission), elated state, convulsions.

Cardio-vascular system and blood (hematopoiesis, hemostasis): hypotension, change in the cellular composition of the blood (reversible leukopenia and agranulocytosis).

Other: abnormal liver function, jaundice, swelling, gynecomastia, arthritis, arthralgia.

Cooperation.

Incompatible with MAO inhibitors (since they require a two-week interval), deprimiruyuschee increases the effects of alcohol, Effects of antihypertensive drugs, ters-anticonvulsants.

Overdose.

Symptoms: prolonged sedation, arrhythmia, convulsions, severe hypotension, respiratory depression. The specific antidote is absent.

Treatment: gastric lavage, simptomaticheskaya therapy, maintaining vital functions.

Dosing and Administration.

Inside, without chewing and drinking water, preferably overnight, several possible techniques. The initial dose - 30 mg, effective-30-90 mg/day (optimally- 60 mg), older — 30 mg/day, with a gradual increase in doses under the supervision of a physician.

Precautions.

With hypomania, convulsive reactions, jaundice mianserin treatment should be discontinued. Avoid the simultaneous use of mianserin with MAO inhibitors, and in the next 2 weeks after the end of the course of treatment with these agents.

It should refrain from driving a car, etc.. active and potentially dangerous activities, requiring attention and quick response, as well as from alcohol. We must carefully monitor patients with heart, renal and / or hepatic insufficiency, narrow-angle glaucoma and suspected prostatic hypertrophy. If you have a fever, faringita, stomatitis or other infectious diseases is mandatory blood test.

Cooperation