Dopamine

When ATH:
C01CA04

Pharmacological action.
Cardiac, gipertenzivnoe, vasodilator, diuretic.

Application.

The shock of different genesis, incl. cardiogenic, postoperative, infectious-toxic, anaphylactic, hypovolemic (Only after the restoration of the bcc), acute cardiovascular and renal failure, hypotension. Poisoning (to increase urine output and accelerate the excretion of xenobiotic).

Contraindications.

Hypersensitivity.

Restrictions apply.

Pheochromocytoma, thyrotoxicosis, severe cardiac arrhythmias, Peripheral Vascular Disease (with obliteration), DGPŽ, bronchial asthma, pregnancy, lactation.

Side effects.

Nausea, vomiting, headache, anxiety, tremor, heart rhythm disturbances, angina, peripheral arterial spasm, pain in the limbs, arterial hypertension, When you get under the skin-necrosis.

Cooperation.

It enhances the effects of sympathomimetic, MAO, diuretics. Incompatible with ergot alkaloids (It increases the risk of developing gangrene).

Overdose.

Heart rhythm disturbances, tachycardia, renal vasoconstriction.

Dosing and Administration.

B /, drop. Adults give speeds of 4-10 mcg/kg/min (maximum — 15-20 mcg/kg/min) continuously, from 2-3 hours to 1-4 days (If necessary, longer), children — with an initial rate of 4-6 mcg/kg/min with a gradual increase in it to 10 ug / kg / min.

Cooperation

Active substance	Description of interaction
Akarʙoza	FMR: antagonizm. Against the background of the effect of dopamine is reduced; with a joint appointment requires constant monitoring of blood glucose concentrations.
Glipizide	FMR: antagonizm. Against the background of the effect of dopamine is reduced; with a joint appointment requires constant monitoring of blood glucose concentrations.
Desmopressin	FMR: synergism. Strengthens (mutually) pressor effect; combined appointment, especially large doses, possible only under constant supervision.
Digoxin	FMR: synergism. Against the background of dopamine increased risk of arrhythmias.
Levothyroxine sodium	FKV. Against the background of the effect of dopamine may vary; while the application requires constant supervision.
Linezolid	FMR: synergism. Increases (some patients) pressor effect; the combined initial appointment is necessary to reduce the dose of the dopamine.
Promethazine	FMR: antagonizm. Weakens effect.
Thiamin	FV. The solutions are not compatible (should not be mixed "in the same syringe").
Phenytoin	Against the background of dopamine can cause hypotension, ʙradikardiju.
Esmolol	FMR. Combined designation are not recommended especially for supraventricular tachycardia (High PR creates the danger threatening weakening of cardiac contractility).