Simvastatin

When ATH:
C10AA01

Characteristic.

White or off-white crystalline powder. Practically insoluble in water, very soluble in chloroform, methanol and ethanol.

Pharmacological action.
Hypocholesteremic.

Application.

Hypercholesterolemia in the absence of effect of diet, Combined hypercholesterolemia and triglyceridemia, CHD, prevention of myocardial infarction and stroke, atherosclerosis.

Contraindications.

Hypersensitivity, acute liver dysfunction, severe renal insufficiency, pregnancy, lactation, childhood.

Pregnancy and breast-feeding.

Category actions result in FDA - X. (Animal tests or clinical trials revealed a violation of the fetus and / or there is evidence of the risk of adverse effects on the human fetus, obtained in research or practice; risk, associated with the use of drugs in pregnancy, greater than the potential benefits.)

Side effects.

Dyspepsia, diarrhea, flatulence, nausea, exacerbation of pancreatitis and hepatitis, transaminase elevation, CNS disorders (headache, paresthesia, convulsions), myalgia, asthenia, myopathy, raʙdomioliz, photosensitivity, allergic reactions (vasculitis, hives, artralgii, thrombocytopenia, eozinofilija, angioedema, symptoms, similar to lupus erythematosus).

Cooperation.

Immunodepressivnaya therapy, high doses of nicotinic acid, antifungals - azole derivatives (ketoconazole, itraconazole) increase the risk of myopathy and rhabdomyolysis. Proximity effect anticoagulants, hepatotoxicity of alcohol and drugs, adverse effects on the liver.

Dosing and Administration.

Inside: in the early course of a single dose of 5-10 mg / day, optionally up 40 mg per day depending on the content of cholesterol and lipoproteins in the blood. In CHD initial dose 20 mg / day one.

Precautions.

Before and during treatment is recommended to monitor liver function and caution is prescribed for her violations.

Cooperation