Nelfinavir

When ATH:
J05AE04

Pharmacological action.
Antiviral, inhibiting HIV protease.

Application.

HIV-1 infection in adults and children (in combination with other antiretroviral drugs from the group of nucleoside analogues).

Contraindications.

Hypersensitivity, pregnancy, lactation.

Side effects.

Diarrhea, flatulence, nausea, stomach ache, asthenia, neutropenia, Lymphocytosis, increase the blood levels of creatine kinase and ALT, rash.

Cooperation.

It enhances the effect of reverse transcriptase inhibitors (zidovudine, lamivudine, didanosine, stavudine). Zidovudine and lamivudine reduce the likelihood of developing resistance. The concentration in blood decreases by background inducers of cytochrome P450 (rifampin, rifabutin, Nevirapine, phenobarbital, phenytoin, and carbamazepine) and increased (while elongation T_1/2) under the influence of anti-HIV drugs (ritonavir, indinavir and saquinavir). It lowers plasma contraceptives (ethinyl estradiol and norethindrone), increases - indinavir, saquinavir, Terfenadine, astemizola, cisapride, calcium channel blockers, prolong the sedative effect of tranquilizers (triazolama, midazolama). Incompatible (inactivated) with food, having an acid reaction (incl. orange and apple juices).

Overdose.

Treatment: nevsosavsheysya part can be removed by induction of vomiting or gastric lavage; It recommended the appointment of activated carbon.

Dosing and Administration.

Inside, preferably during meals. Adults and children over 13 years - 750 mg (3 Table. by 350 mg) 3 once a day; Children up to 13 years - 20–30 mg/kg 3 once a day; if you can not swallow a pill prescribed powder: children weighing from 7,5 to 10 kg - 4 measuring spoons or 1 teaspoon of powder, from 10 to 12 kg - 5 measuring spoons or 1,25 teaspoons of powder, from 12 to 15 kg - 6 measured or 1,5 teaspoons of powder, from 15 to 20 kg - 2 Table. or 8 dimensional (2 c.logki) powder, from 20 to 30 kg - 2 Table. or 3 teaspoons of powder, from 30 to 40 kg and more 3 Table. or 4 teaspoons of powder.

Precautions.

The powder can be mixed with water, milk, incl. soy, mixtures for artificial feeding, incl. soy, pudding, etc.. However, it is recommended to store such mixtures no more than 6 no. Avoid getting water into the vial with powder. Care must be taken in the human liver, gemofilii (It increases the risk of bleeding, the appearance of spontaneous subcutaneous hematoma and hemarthrosis). Because the safety of the children to 2 s is not installed, appointed (in the form of powder) only, if the potential benefits of therapy exceeds potential risk.