Neyromultivit
Active material: Цianokoʙalamin, Pyridoxine, Thiamin
When ATH: A11DB
CCF: The complex B vitamins
ICD-10 codes (testimony): G50.0, G51, G60, G61, G62.1, G63.2, M54.1, M54.3, M54.4, M79.2
When CSF: 02.11.01
Manufacturer: LANNACHER HEILMITTEL Ges.m.b.H. (Austria)
Pharmaceutical form, composition and packaging
Pills, Film-coated white or nearly white, round, lenticular.
| 1 tab. | |
| thiamine hydrochloride (wreathed. B1) | 100 mg |
| pyridoxine hydrochloride (wreathed. B6) | 200 mg |
| цianokoʙalamin (wreathed. B12) | 200 g |
Excipients: microcrystalline cellulose, magnesium stearate, povidone, macrogol 6000, Titanium dioxide, talc, gipromelloza, Eudrajit NE30D (methacrylic acid and ethacrylate copolymer).
20 PC. – packings Valium planimetric (1) – packs cardboard.
Pharmacological action
Thiamin (vitamin B1) in the human body as a result of processes of phosphorylation turns into kokarboksilazu, which is a coenzyme of many enzyme reactions. Thiamine plays an important role in carbohydrate, protein and fat metabolism. Actively involved in the processes of neural excitation in the synapses.
Pyridoxine (vitamin B6) necessary for normal functioning of the central and peripheral nervous system. The phosphorylated form is a coenzyme in the metabolism of amino acids (incl. decarboxylation, transamination). Acts as a coenzyme important enzymes, active in nerve tissues. Participates in the biosynthesis of neurotransmitters, such as dopamine, noradrenaline, adrenaline, E histamine GABA.
Цianokoʙalamin (vitamin B12) is necessary for normal blood formation and maturation of red blood cells, and also participates in a number of biochemical reactions, ensure the functioning of the body (in the transfer of methyl groups, in the synthesis of nucleic acids, squirrel, in the metabolism of amino acids, carbohydrates, lipids). It has an impact on the processes in the nervous system (RNA synthesis, DNA) and the lipid composition of phospholipids and cerebrosides. Coenzyme form cyanocobalamin – methylcobalamin and adenosyl cobalamin – necessary for the replication and growth of cells.
Pharmacokinetics
The components of the drug is water-soluble vitamins, which excludes the possibility of their accumulation in the body.
Absorption and distribution
Thiamine and Pyridoxine absorbed in the upper intestine, the degree of absorption depends on the dose.
The absorption of cyanocobalamin is largely determined by the presence of intrinsic factor in the stomach and upper intestine, in the future delivery of cyanocobalamin in the tissue is carried out transport protein transcobalamin II.
Metabolism
Thiamin, pyridoxine, and cyanocobalamin is metabolized in the liver.
Deduction
Thiamine and pyridoxine the kidneys (about 8-10% – in unchanged form). In overdose greatly increases the excretion of thiamine, and pyridoxine through the intestine.
Cyanocobalamin is derived mainly from the bile, degree of excretion by the kidneys is variable – from 6 to 30%.
Testimony
In the complex treatment of these neurological diseases:
- Polyneuropathy of different etiologies (incl. Diabetic, Alcoholic);
- Neuritis and neuralgia;
- Radicular syndrome, caused by degenerative changes of the spine;
- Sciatica;
- Lyumbago;
- Plexitis;
- Mezhrebernaya neuralgia;
- Neuralgia nerve troynichnogo;
- Paresis of the facial nerve.
Dosage regimen
Assign inside of 1 tab. 1-3 times / day. Duration of the course is determined individually.
Tablets should be taken after a meal, liquid squeezed small amounts of liquid.
Side effect
In rare cases,: nausea, tachycardia, skin reactions such as itching and hives.
The drug was well tolerated.
Contraindications
- Hypersensitivity to the drug.
Pregnancy and lactation
Not recommended for use Neyromultivit® Pregnancy and lactation (breast-feeding) due to the lack of reliable clinical data, confirming the safety of the drug in these periods.
Cautions
Do not use the drug in high doses over 4 weeks.
Overdose
Currently, cases of drug overdose Neyromultivit® not reported.
Drug Interactions
In an application Neyromultivita® and levodopa, there is a decrease the effectiveness of levodopa antiparkinsonian.
The combined application Neyromultivita® and ethanol dramatically reduces the absorption of thiamine, part of the drug (blood levels may be reduced by 30%).
During treatment Neyromultivitom® not recommend taking multivitamin complexes, is included in B vitamins.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
The drug should be stored in a dry, protected from light, inaccessible to children at temperature not exceeding 25 ° C. Shelf life – 3 year.
