Цianokoʙalamin
When ATH:
B03BA01
Characteristic.
Vitamin B12. The crystalline hygroscopic powder dark red, without smell. It is soluble in water, solutions are red (or pink) color. Long autoclaving, oxidizing or reducing substances (vitamin C), salts of heavy metals contribute to the inactivation; It is rapidly degraded by microflora, therefore solutions should be stored under aseptic conditions.
Pharmacological action.
Hematopoietic, erythropoietic, antianemic, metabolic.
Application.
Chronic anemia, proceeding with a deficiency of vitamin B12 (Addison-Biermer, alimentary macrocytic), in complex therapy of anemia is iron deficiency, posthemorrhagic, aplastic, caused by toxicants and drugs, myelosis, traumatic injuries and inflammation of the peripheral nerves (wound, radikulonevrit, neuritis, neuralgia, kauzalgija, phantom pain), amyotrophic lateral sclerosis, encephalomyelitis, multiple sclerosis, diabetic neuropathy, cerebral palsy, congenital acromicria, skin diseases (psoriasis, photodermatoses, dermatitis herpetiformis, neurodermatitis), traumatic injuries of bones and condition after surgery on the locomotor system by slowing down bone consolidation, acute and chronic hepatitis, cirrhosis of the liver, radiation sickness. The objective — when appointing biguanide, p-aminosalicylic acid, high doses of vitamin C., in the pathology of gastric and intestinal, prevents normal absorption of vitamin (resection of the stomach, small intestine, Crohn's disease, celiac disease, sprue).
Contraindications.
Hypersensitivity, hypercoagulation (incl. acute thrombosis), erythremia, эritrotsitoz.
Restrictions apply.
With care and in smaller doses administered angina, benign and malignant tumors (apply only in cases, accompanied by megaloblastic anemia and deficiency of vitamin B12).
Side effects.
Headache, dizziness, excitation, precordialgia, tachycardia, allergic reactions (hives).
Cooperation.
Pharmaceutically (in the same syringe) incompatible with solutions of vitamins, B1 and B6 (cobalt ion contributes to the destruction of other vitamins). It increases the likelihood of allergic reactions, caused by vitamin B1.
Dosing and Administration.
Inside, n / a, / m, I / O and intralyumbalno. With anemia Addison-Biermer on 100-200 micrograms a day-; with anemia Addison-Biermer events funikulyarnogo mieloza and macrocitarnah anemiah human nervous system is on 500 mcg or more on injection (in the first week — daily, and then at intervals between wvedeniami to 5-7 days). At the same time prescribe folic acid. During remission in the absence of events funikulyarnogo mieloza impose a maintenance therapy 100 g 2 once a month, and the availability of neurological events — for 200-400 micrograms 2-4 times per month. When transmitted and postgemorragicakih anemiah on 30-100-µg 2-3 times a week. When aplastic anemia (especially in children) - By 100 mcg before the onset of clinical and Hematological improvement. In the nutritional anaemia in children at an early age and the weight-on 30 micrograms per day for 15 days; in CNS diseases and neurological diseases with pain is administered in increasing dosages of 200 to 500 mcg injection, and in improving-on 100 ug per day; the course is to 2 Sun; when traumatic lesions peripheral nerves — for 200-400 micrograms a day for 40-45 days. Hepatitis and liver cirrozah is on 30-60 micrograms per day or 100 micrograms a day for 25-40 days; dystrophy in young children, down's syndrome and childhood cerebral palsy — on 15-30 micrograms a day; at sprue, radiation sickness, diabetic neuropathy appoint 60-100 micrograms daily for 20-30 days. When funicular myelosis, Bokova amiotrofičeskom sclerosis, multiple sclerosis misleading sometimes spinal canal to 15-30 micrograms (gradually increasing the dose to 200-250 mg).
Precautions.
During treatment should regularly monitor the blood count and clotting.
