Витамин B6. It plays an important role in metabolism; necessary for normal functioning of the central and peripheral nervous system. The phosphorylated pyridoxine is a coenzyme form of a large number of enzymes, acting on a non-oxidative exchange of amino acids (incl. the processes of decarboxylation, transamination). Pyridoxine is involved in the metabolism of tryptophan, methionine, cysteine, glutamic and other amino acids. It plays an important role in the metabolism of histamine. Pyridoxine helps to normalize lipid metabolism.
It is metabolized in the liver with the formation of the pharmacologically active metabolite (pyridoxal phosphate and piridoksaminofosfat). Distribution primarily muscle, liver and central nervous system. It penetrates through the placenta and into the mother's milk. Report the news (at / in the introduction of gall – 2%).
Treatment and prevention of clinical deficiency of vitamin B6.
For the treatment of vitamin B6 adult inside – by 80 mg 4 times / day. It is also possible to / m, subcutaneous or in / in a daily dose 50-150 mg. The duration of treatment is determined by the type and severity of the disease.
For the prevention of vitamin B6 used at a dose 40 mg / day.
In some cases,: allergic reactions, hypersecretion of hydrochloric acid.
Hypersensitivity to pyridoxine.
Pregnancy and lactation
Perhaps the use of pyridoxine during pregnancy and lactation (breast-feeding) on indications.
To use caution in gastric ulcer and duodenal ulcer, CHD.
In severe liver damage pyridoxine in high doses can cause deterioration of its function.
While the use of hormonal contraceptives may increase the concentration in the blood plasma of pyridoxine.
In an application potentiated the effect of diuretics.
While the use of levodopa reduced or completely inhibited the effects of levodopa.
In an application with izonikotingidrazidom, penicillamine, cycloserine may decrease the effectiveness of pyridoxine.
In an application with phenytoin, phenobarbital may decrease plasma concentrations of phenytoin and phenobarbital.