Liotironin

When ATH:
H03AA02

Pharmacological action.
Fill the shortage of thyroid hormones.

Application.

Primary hypothyroidism, myxedema, kretinizm, tserebrogipofizarnye with hypothyroid disease states, hypothyroid obesity, endemic and sporadic goiter, thyroid cancer, Diagnosis of hypothyroidism.

Contraindications.

Hypersensitivity, thyrotoxicosis, diabetes, Addison's disease, adrenal insufficiency, kaxeksija, CHD.

Pregnancy and breast-feeding.

Category actions result in FDA - A. (As a result, adequate and well-controlled studies have found the risk of adverse effects on the fetus in the I trimester of pregnancy and there is no data, evidence of such a risk in subsequent trimesters.)

Side effects.

Headache, irritability, tachycardia, arrhythmia, angina, heart failure, dysmenorrhoea, allergic reactions.

Cooperation.

It increases the effect of oral anticoagulants, vasoconstrictors, reduces-insulin and other gipoglikemicakih funds. Activity decreases oral contraceptives and kolestiraminom. It increases the likelihood of adverse events in the appointment of antidepressants, cardiac glycosides, ketamine.

Dosing and Administration.

Inside. If gipotireodnyh States appoint 25 mg / day, may increase dose to 25 mcg every 1-2 weeks. Supporting dose is 25-75 mcg. When miksedeme the initial dose is 5 mg / day, increased every 1-2 weeks at 5-10 µg, upon reaching the dose 25 g/day further enhancing produce 5-25 g/day every 1-2 weeks. Supporting dose is 50-100 mcg/day. If a nontoxic goiter starting dose (5 mg / day) increase 5-10 µg every 1-2 weeks. The maintenance dose is usually 75 mg / day.

Cooperation

Active substance	Description of interaction
Akarʙoza	FMR: antagonizm. Against the background of the effect of liothyronine weakened (with a joint appointment requires constant monitoring of blood glucose concentrations).
Glipizide	FMR: antagonizm. Against the background of the effect of liothyronine weakened (with a joint appointment requires constant monitoring of blood glucose levels).
Ketamine	FMR. Increases concentration in the blood and the risk of side effects.
Protirelin	FMR. Against the background of liothyronine reduced TSH response to protirelin.
Phenytoin	FKV. FMR. Increases concentration in the blood and the risk of side effects.
Furosemid	FKV. FMR. Increases (large doses) concentration and the risk of side effects.